IMC22

IMC22 is a component of the inner membrane complex (IMC) of Toxoplasma gondii, an organelle composed of alveolar sacs and an underlying cytoskeletal network, identified through proximity-dependent biotin identification (BioID) using known IMC proteins as bait (PMID:25691595). Beyond this proximity-based assignment to the IMC compartment, nothing further about the molecular function of IMC22 has been characterized in the available corpus.

1. 2015 Medium

   The composition of the Toxoplasma IMC was incompletely defined; BioID proximity labeling with known IMC baits established IMC22 as a previously unrecognized resident of this organelle.

   Evidence BioID proximity-dependent biotin identification with IMC-protein baits followed by mass spectrometry in T. gondii

   PMID:25691595

   Open questions at the time

   • No functional knockout or knockdown of IMC22 was performed
   • No orthogonal localization validation specific to IMC22 was reported
   • Whether IMC22 associates with the alveolar sac membranes or the cytoskeletal network was not resolved