IMC23

IMC23 is a component of the Toxoplasma gondii inner membrane complex (IMC), an organelle composed of alveolar sacs overlying a cytoskeletal network, identified by BioID proximity-dependent biotinylation using known IMC proteins as bait (PMID:25691595). Beyond this proximity-based assignment to the IMC compartment (PMID:25691595), no further mechanistic detail about IMC23's molecular function has been characterized in the available corpus.

1. 2015 Medium

   Before this work IMC23 was uncharacterized; proximity labeling with known IMC baits established that IMC23 resides within the IMC organelle, placing it among the parasite's alveolar/cytoskeletal machinery.

   Evidence BioID proximity-dependent biotinylation with IMC protein baits followed by mass spectrometry in T. gondii

   PMID:25691595

   Open questions at the time

   • BioID reports proximity, not direct interaction, so IMC23's binding partners within the IMC are undefined
   • IMC23 was not functionally validated by knockout, so its role in the IMC is unknown
   • Sub-compartment localization (alveolar membrane vs cytoskeletal network) was not resolved