Affinage · Toxoplasma gondii

TSC6

transverse sutures component TSC6 · UniProt S8FFI1

Annotated
2026-09-10
1 papers in source corpus 1 papers cited in narrative 1 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TSC6 is a component of the Toxoplasma gondii inner membrane complex (IMC) that localizes exclusively to the transverse sutures, identified as one of five transverse sutures components through proximity-dependent biotinylation (BioID) using ISC4 as bait (PMID:27696623). Beyond this localization assignment, no functional characterization of TSC6 has been reported in the available corpus.

Mechanistic history

Synthesis pass · year-by-year structured walk · 1 step
  1. 2016 Medium

    The composition of the Toxoplasma IMC transverse sutures was incompletely defined; BioID mapping established TSC6 as a protein restricted to this substructure, placing it within the suture proteome.

    Evidence Proximity-dependent biotin identification (BioID) with ISC4 as bait, followed by localization validation, in Toxoplasma gondii

    PMID:27696623

    Open questions at the time
    • No molecular function or biochemical activity for TSC6 has been determined
    • Direct binding partners of TSC6 within the suture are not defined
    • The phenotypic consequence of TSC6 loss is unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification
Partners
ISC4 (BIOID BAIT USED TO IDENTIFY TSC6)
Complex memberships
Toxoplasma IMC transverse sutures (TSC) proteome

Evidence

Reading pass · 1 per-paper finding extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 TSC6 was identified as one of five new proteins that exclusively localize to the transverse sutures of the Toxoplasma IMC, establishing it as a transverse sutures component (TSC); this localization was determined using proximity-dependent biotin identification (BioID) with ISC4 as bait. Proximity-dependent biotin identification (BioID) followed by localization validation Cellular microbiology Medium 27696623

Source papers

Stage 0 corpus · 1 paper · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 Novel insights into the composition and function of the Toxoplasma IMC sutures. Cellular microbiology 59 27696623