Affinage · Toxoplasma gondii

MyoL

myosin head (motor domain) domain-containing protein · UniProt S8F3J9

Annotated
2026-09-10
1 papers in source corpus 1 papers cited in narrative 1 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MyoL is one of the eleven Toxoplasma gondii myosins whose folding, assembly, and function depend on the co-chaperone TgUNC; conditional ablation of TgUNC recapitulates the collective myosin phenome, including defects in basal complex constriction and synchronized intravacuolar division (PMID:28593938). No experiment has individually characterized MyoL's substrates, localization, motor activity, or specific cellular function in the available corpus.

Mechanistic history

Synthesis pass · year-by-year structured walk · 1 step
  1. 2017 Low

    It was unknown whether Toxoplasma myosins share a common maturation pathway; conditional TgUNC ablation showed that TgUNC is a dedicated chaperone required for the folding and assembly of the full myosin repertoire, placing MyoL within a TgUNC-dependent set of motors and linking loss of this pathway to defects in basal complex constriction and synchronized division.

    Evidence Conditional ablation (TgUNC knockdown) with phenotypic readouts of motility, invasion, egress, basal complex constriction, and synchronized division in Toxoplasma gondii

    PMID:28593938

    Open questions at the time
    • MyoL is addressed only as part of the collective myosin repertoire; no experiment resolves MyoL's individual function
    • MyoL's subcellular localization has not been determined
    • MyoL's substrates, binding partners, and motor activity are uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification
Partners
TGUNC (CHAPERONE REQUIRED FOR FOLDING AND ASSEMBLY OF MYOL, SHOWN AT THE LEVEL OF THE FULL TOXOPLASMA MYOSIN REPERTOIRE) [#0]

Evidence

Reading pass · 1 per-paper finding extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2017 TgUNC acts as a chaperone dedicated to the folding, assembly, and function of all Toxoplasma myosins, including MyoL (a class myosin with a motor domain); conditional ablation of TgUNC recapitulates the phenome of the known myosins and uncovers roles in basal complex constriction and synchronized division within the parasitophorous vacuole across the full myosin repertoire. Conditional ablation (TgUNC knockdown) with phenotypic readouts of motility, invasion, egress, basal complex constriction, and synchronized division Nature Communications Low 28593938

Source papers

Stage 0 corpus · 1 paper · ranked by NIH iCite citations
Year Title Journal Citations PMID
2017 Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii. Nature communications 90 28593938