IMC17

IMC17 is a novel protein component of the Toxoplasma gondii inner membrane complex (IMC), identified by proximity-dependent biotin identification (BioID) using established IMC proteins as bait and localized to the IMC suborganellar compartment by fluorescence microscopy (PMID:25691595). Beyond this identification and localization, nothing further about the molecular function of IMC17 has been characterized in the available corpus.

1. 2015 Medium

   Whether IMC17 was a bona fide constituent of the Toxoplasma IMC was unknown; BioID proximity labeling with known IMC proteins placed IMC17 within the IMC compartment, establishing it as a novel resident of this suborganellar structure.

   Evidence BioID proximity labeling in T. gondii with IMC-protein bait, mass spectrometry, and fluorescence localization

   PMID:25691595

   Open questions at the time

   • IMC17 was identified but not subjected to functional knockout evaluation, so its role in the IMC is undefined
   • No direct binding partners or substrates of IMC17 have been resolved
   • The submembrane positioning of IMC17 within the IMC (cytoskeletal vs. membrane sublayer) is not established