Affinage · Toxoplasma gondii

BCC11

basal complex component BCC11 · UniProt S8GAK9

Annotated
2026-09-10
1 papers in source corpus 1 papers cited in narrative 1 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

BCC11 is a component of the Toxoplasma gondii basal complex, identified through reciprocal proximity-based biotinylation (BioID) proteomics that mapped the basal complex into four architecturally distinct subcomplexes whose composition changes dynamically in correlation with basal complex function during cell division (PMID:35941170). Beyond its assignment to one of these subcomplexes (PMID:35941170), no further mechanistic detail about BCC11's specific molecular function has been characterized in the available corpus.

Mechanistic history

Synthesis pass · year-by-year structured walk · 1 step
  1. 2022 Medium

    To resolve the composition and architecture of the Toxoplasma basal complex, proximity proteomics placed BCC11 within one of four distinct subcomplexes, establishing it as a bona fide basal complex constituent linked to cell division.

    Evidence Reciprocal proximity-based biotinylation (BioID) proteomics with spatiotemporal disruption of component expression in Toxoplasma gondii

    PMID:35941170

    Open questions at the time
    • BCC11's specific molecular function within the basal complex is not defined
    • No direct binding partners or substrate of BCC11 identified
    • The consequence of BCC11 loss on basal complex function or division is not individually reported

Mechanism profile

Synthesis pass · controlled-vocabulary classification
Complex memberships
Toxoplasma gondii basal complex (one of four architecturally distinct subcomplexes)

Evidence

Reading pass · 1 per-paper finding extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2022 BCC11 was identified as a component of the Toxoplasma gondii basal complex (BC) proteome through a reciprocal proximity-based biotinylation (BioID) approach, placing it within one of four architecturally distinct BC subcomplexes whose composition changes dynamically in correlation with changes in BC function during cell division. Reciprocal proximity-based biotinylation (BioID) proteomics; spatiotemporal disruption of component expression Nature Communications Medium 35941170

Source papers

Stage 0 corpus · 1 paper · ranked by NIH iCite citations
Year Title Journal Citations PMID
2022 Proteomic characterization of the Toxoplasma gondii cytokinesis machinery portrays an expanded hierarchy of its assembly and function. Nature communications 46 35941170