Affinage · Toxoplasma gondii

BCC8

basal complex component BCC8 · UniProt S8GA19

Annotated
2026-09-10
1 papers in source corpus 1 papers cited in narrative 1 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

BCC8 is a component of the Toxoplasma gondii basal complex, a cytoskeletal structure identified through reciprocal proximity-based biotinylation (BioID) proteomics as being organized into four architecturally distinct subcomplexes whose compositions change dynamically in correlation with changes in basal complex function during cell division (PMID:35941170). Beyond its assignment as a basal complex component in this proteomic survey, no specific molecular function has been characterized for BCC8 in the available corpus.

Mechanistic history

Synthesis pass · year-by-year structured walk · 1 step
  1. 2022 Medium

    Before this work the full protein composition of the Toxoplasma basal complex was unresolved; mapping it established BCC8 as a bona fide basal complex component within one of four dynamically changing subcomplexes.

    Evidence Reciprocal proximity-based biotinylation (BioID) proteomics with component disruption and spatiotemporal/functional readouts in Toxoplasma gondii

    PMID:35941170

    Open questions at the time
    • No functional experiment specific to BCC8 alone was performed
    • The subcomplex assignment and precise substructure localization of BCC8 within the basal complex is not defined
    • The molecular activity and interaction partners of BCC8 are unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification
Complex memberships
Toxoplasma gondii basal complex

Evidence

Reading pass · 1 per-paper finding extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2022 BCC8 was identified as a component of the Toxoplasma gondii basal complex (BC) proteome through a reciprocal proximity-based biotinylation (BioID) approach; the BC is organized into four architecturally distinct subcomplexes whose compositions change dynamically in correlation with changes in BC function during cell division. Reciprocal proximity-based biotinylation (BioID) proteomics; disruption of component expression with spatiotemporal and functional readouts Nature Communications Medium 35941170

Source papers

Stage 0 corpus · 1 paper · ranked by NIH iCite citations
Year Title Journal Citations PMID
2022 Proteomic characterization of the Toxoplasma gondii cytokinesis machinery portrays an expanded hierarchy of its assembly and function. Nature communications 46 35941170