Affinage · Toxoplasma gondii

IMC40

inner membrane complex protein IMC40 · UniProt S8F1B8

Annotated
2026-09-10
1 papers in source corpus 1 papers cited in narrative 1 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

IMC40 is a novel inner membrane complex (IMC) protein of Toxoplasma gondii identified as one of eight daughter-bud-enriched proteins that expand the daughter IMC proteome, detected by proximity labeling centered on IMC29 (PMID:36622147). Beyond this proximity-based identification and its daughter-bud enrichment, no molecular function for IMC40 has been characterized in the available corpus.

Mechanistic history

Synthesis pass · year-by-year structured walk · 1 step
  1. 2023 Low

    To expand the catalog of proteins operating at the daughter inner membrane complex during endodyogeny, IMC40 was placed within the daughter IMC proteome as a proximity partner of IMC29.

    Evidence BioID proximity labeling using IMC29 as bait followed by mass spectrometry in Toxoplasma gondii

    PMID:36622147

    Open questions at the time
    • Single proximity-labeling experiment with no functional characterization of IMC40 itself
    • Direct interaction versus mere proximity to IMC29 not resolved
    • No knockout, localization detail, or role in bud formation established

Mechanism profile

Synthesis pass · controlled-vocabulary classification
Partners
IMC29 (PROXIMITY PARTNER IN BIOID)

Evidence

Reading pass · 1 per-paper finding extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2023 IMC40 was identified as one of eight novel IMC proteins enriched in daughter buds, expanding the daughter IMC proteome, via proximity labeling centered on IMC29. Proximity labeling (BioID) using IMC29 as bait, followed by mass spectrometry identification mBio Low 36622147

Source papers

Stage 0 corpus · 1 paper · ranked by NIH iCite citations
Year Title Journal Citations PMID
2023 IMC29 Plays an Important Role in Toxoplasma Endodyogeny and Reveals New Components of the Daughter-Enriched IMC Proteome. mBio 30 36622147