Affinage · Toxoplasma gondii

BCC5

Ser/Thr phosphatase family protein · UniProt S8G9D7

Annotated
2026-09-10
1 papers in source corpus 1 papers cited in narrative 1 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

BCC5 is a component of the Toxoplasma gondii basal complex, identified within the basal complex proteome through reciprocal proximity-based biotinylation (BioID) mapping of the basal complex and its architecturally distinct subcomplexes (PMID:35941170). Beyond this proteomic assignment, no specific molecular activity, binding partner, or functional role has been experimentally defined for BCC5 in the available corpus.

Mechanistic history

Synthesis pass · year-by-year structured walk · 1 step
  1. 2022 Low

    Establishing which proteins constitute the Toxoplasma basal complex was needed to define the machinery of parasite cell division; BioID mapping placed BCC5 among the basal complex components.

    Evidence Reciprocal proximity-based biotinylation (BioID) proteomics of the basal complex in T. gondii

    PMID:35941170

    Open questions at the time
    • No functional experiment on BCC5 itself; assignment rests on proximity proteomics from a single method and lab
    • No binding partner, substrate, or molecular activity defined for BCC5
    • Precise subcomplex localization and role in division not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification
Complex memberships
Toxoplasma gondii basal complex

Evidence

Reading pass · 1 per-paper finding extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2022 BCC5 was identified as a component of the Toxoplasma gondii basal complex (BC) proteome through a reciprocal proximity-based biotinylation (BioID) approach that mapped the BC and its four architecturally distinct subcomplexes with spatiotemporal dynamics. Reciprocal proximity-based biotinylation (BioID) proteomics of the basal complex Nature communications Low 35941170

Source papers

Stage 0 corpus · 1 paper · ranked by NIH iCite citations
Year Title Journal Citations PMID
2022 Proteomic characterization of the Toxoplasma gondii cytokinesis machinery portrays an expanded hierarchy of its assembly and function. Nature communications 46 35941170