ISC6

ISC6 is a component of the inner membrane complex (IMC) sutures of Toxoplasma gondii, localizing to both the transverse and longitudinal sutures of this organelle, where it was identified as a new IMC sutures component (ISC) by proximity-dependent biotin labeling using ISC4 as bait (PMID:27696623). Beyond this localization within the IMC suture system, no further mechanistic detail about ISC6 has been characterized in the available corpus.

1. 2016 Medium

   To define the protein composition of the Toxoplasma IMC sutures, ISC6 was sought as a suture-associated protein; its identification established a previously unknown component localizing to both transverse and longitudinal sutures.

   Evidence BioID proximity-dependent biotin labeling with ISC4 as bait followed by fluorescence localization in Toxoplasma gondii

   PMID:27696623

   Open questions at the time

   • Molecular function and any enzymatic or structural activity of ISC6 are undefined
   • Direct binding partners beyond proximity to the ISC4 bait are not established
   • Contribution of ISC6 to IMC integrity, cytokinesis, or parasite fitness has not been tested