Affinage · Toxoplasma gondii

IMC31

inner membrane complex protein IMC31 · UniProt A0A125YWL6

Annotated
2026-09-10
1 papers in source corpus 1 papers cited in narrative 1 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

IMC31 is a novel inner membrane complex protein of Toxoplasma gondii identified as one of eight IMC proteins enriched in daughter buds during endodyogeny, discovered through proximity labeling anchored to the daughter IMC protein IMC29 (PMID:36622147). Beyond this identification, nothing further is known about IMC31 in the available corpus.

Mechanistic history

Synthesis pass · year-by-year structured walk · 1 step
  1. 2023 Low

    The daughter-bud IMC proteome was incompletely defined; anchoring proximity labeling to IMC29 revealed IMC31 as a novel constituent enriched in forming daughter buds, placing it within the machinery of Toxoplasma replication.

    Evidence BioID proximity labeling using IMC29 as bait followed by mass spectrometry in Toxoplasma gondii

    PMID:36622147

    Open questions at the time
    • Identification by proximity labeling only, with no functional follow-up specific to IMC31
    • Precise subcellular localization within the IMC and interaction partners not established
    • No genetic knockout or phenotype characterizing IMC31's role in daughter bud formation

Mechanism profile

Synthesis pass · controlled-vocabulary classification
Partners
IMC29 (PROXIMITY-LABELING BAIT USED TO IDENTIFY IMC31) [#0]

Evidence

Reading pass · 1 per-paper finding extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2023 IMC31 was identified as one of eight novel IMC proteins enriched in daughter buds, discovered via proximity labeling anchored to IMC29, significantly expanding the daughter IMC proteome. Proximity labeling (BioID) with IMC29 as bait, followed by mass spectrometry identification mBio Low 36622147

Source papers

Stage 0 corpus · 1 paper · ranked by NIH iCite citations
Year Title Journal Citations PMID
2023 IMC29 Plays an Important Role in Toxoplasma Endodyogeny and Reveals New Components of the Daughter-Enriched IMC Proteome. mBio 30 36622147