AC5

AC5 is a component of the Toxoplasma gondii inner membrane complex (IMC), identified by proximity-dependent biotin identification (BioID) using IMC proteins as bait and localizing to a suborganellar compartment of the IMC, the apical cap (PMID:25691595). Beyond this localization within the IMC, no further mechanistic detail for AC5 has been characterized in the available corpus.

1. 2015 Medium

   Before this work the protein composition of the T. gondii IMC and its suborganellar sub-domains was incompletely defined; BioID established AC5 as a bona fide IMC-associated protein localizing to a discrete apical cap compartment, placing it within the parasite's pellicular cytoskeletal architecture.

   Evidence BioID proximity labeling with IMC proteins as bait in T. gondii, with localization

   PMID:25691595

   Open questions at the time

   • Molecular function of AC5 within the IMC not experimentally established
   • No knockout or functional characterization of AC5 in this study
   • Direct binding partners and mechanism of recruitment to the apical cap unknown