PCR3

PCR3 is a component of the preconoidal rings (PCRs) of Toxoplasma gondii, apical cytoskeletal structures that serve as a hub for glideosome components including Formin1, thereby linking the PCRs to the actomyosin machinery underlying gliding motility and invasion (PMID:36109645). Beyond its identification as a PCR constituent, no PCR3-specific molecular mechanism or direct binding partner has been characterized in the available corpus.

1. 2022 Medium

   Whether the preconoidal rings organize glideosome components was unknown; imaging the apical complex at high resolution established that the PCRs—of which PCR3 is a compositional member—act as a hub concentrating glideosome factors such as Formin1.

   Evidence Ultrastructure expansion microscopy (U-ExM) in Toxoplasma gondii

   PMID:36109645

   Open questions at the time

   • No PCR3-specific experiments distinguish its role from the broader PCR complex
   • No direct binding partner of PCR3 has been identified
   • The molecular contribution of PCR3 to Formin1 recruitment or motility is undefined