Affinage · Toxoplasma gondii

IMC19

inner membrane complex protein IMC19 · UniProt S8G8Y2

Annotated
2026-09-10
1 papers in source corpus 1 papers cited in narrative 1 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

IMC19 is a component of the inner membrane complex (IMC) of Toxoplasma gondii, identified through BioID proximity labeling and localizing to a specific suborganellar subcompartment of the IMC, either its alveolar membranes or the underlying cytoskeletal network (PMID:25691595). Beyond this identification and localization, no further mechanistic detail about IMC19 has been characterized in the available corpus.

Mechanistic history

Synthesis pass · year-by-year structured walk · 1 step
  1. 2015 Medium

    The composition of the Toxoplasma IMC was incompletely defined; applying BioID proximity labeling to the IMC established IMC19 as a bona fide novel constituent and placed it within a defined IMC subcompartment.

    Evidence BioID proximity labeling followed by mass spectrometry identification in T. gondii

    PMID:25691595

    Open questions at the time
    • No molecular activity or biochemical function assigned to IMC19
    • Precise assignment between alveolar membranes versus cytoskeletal network not resolved
    • No direct binding partners or complex membership validated for IMC19

Mechanism profile

Synthesis pass · controlled-vocabulary classification
Complex memberships
inner membrane complex (IMC)

Evidence

Reading pass · 1 per-paper finding extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2015 IMC19 was identified as a novel component of the Toxoplasma gondii inner membrane complex (IMC) using proximity-dependent biotin identification (BioID), localizing to a specific suborganellar compartment of the IMC (alveoli or cytoskeletal network). BioID proximity labeling in T. gondii, followed by mass spectrometry identification mBio Medium 25691595

Source papers

Stage 0 corpus · 1 paper · ranked by NIH iCite citations
Year Title Journal Citations PMID
2015 Novel components of the Toxoplasma inner membrane complex revealed by BioID. mBio 148 25691595