Affinage · Toxoplasma gondii

BCC9

basal complex component BCC9 · UniProt A0A125YJ55

Annotated
2026-09-10
1 papers in source corpus 1 papers cited in narrative 1 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

BCC9 is a component of the Toxoplasma gondii basal complex, identified through reciprocal proximity-based biotinylation (BioID) proteomics as part of one of four architecturally distinct basal complex subcomplexes whose compositions change dynamically in correlation with basal complex function during cell division (PMID:35941170). Beyond its assignment as a basal complex component (PMID:35941170), no further mechanistic detail about BCC9 has been characterized in the available corpus.

Mechanistic history

Synthesis pass · year-by-year structured walk · 1 step
  1. 2022 Medium

    Establishing which proteins populate the Toxoplasma basal complex was needed to understand its architecture; BCC9 was placed within one of four distinct basal complex subcomplexes, defining it as a bona fide basal complex component.

    Evidence Reciprocal proximity-based biotinylation (BioID) proteomics with spatiotemporal and functional interrogation in Toxoplasma gondii

    PMID:35941170

    Open questions at the time
    • No specific molecular function for BCC9 within the basal complex was determined
    • Direct binding partners and substrate/interaction interfaces of BCC9 are not resolved
    • The consequence of BCC9 loss on basal complex assembly or cell division is not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification
Complex memberships
Toxoplasma gondii basal complex (one of four architecturally distinct subcomplexes)

Evidence

Reading pass · 1 per-paper finding extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2022 BCC9 was identified as a component of the Toxoplasma gondii basal complex (BC) proteome through a reciprocal proximity-based biotinylation (BioID) approach, placing it within one of four architecturally distinct BC subcomplexes whose compositions change dynamically in correlation with changes in BC function during cell division. Reciprocal proximity-based biotinylation (BioID) proteomics with spatiotemporal and functional interrogation by disrupting expression of components Nature communications Medium 35941170

Source papers

Stage 0 corpus · 1 paper · ranked by NIH iCite citations
Year Title Journal Citations PMID
2022 Proteomic characterization of the Toxoplasma gondii cytokinesis machinery portrays an expanded hierarchy of its assembly and function. Nature communications 46 35941170