IMC36

IMC36 is a novel inner membrane complex protein of Toxoplasma gondii identified as one of eight IMC proteins enriched in daughter buds through proximity labeling from IMC29, an assignment that expands the daughter IMC proteome (PMID:36622147). Beyond this proximity-based localization to the daughter-bud IMC, nothing further about IMC36's molecular function or mechanism has been characterized in the available corpus.

1. 2023 Low

   The daughter IMC proteome was incompletely defined; identifying new components addresses which proteins populate the developing daughter bud during endodyogeny.

   Evidence Proximity labeling (BioID) from IMC29 in Toxoplasma gondii

   PMID:36622147

   Open questions at the time

   • Single proximity-labeling screen with no direct functional characterization of IMC36
   • No knockout, knockdown, or phenotype established for IMC36
   • Molecular activity and direct binding partners of IMC36 unknown