- Annotated
- 2026-09-08
43 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 43 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 1996 | Purification and cloning of a soluble ATP-diphosphohydrolase (apyrase) from potato tubers (Solanum tuberosum). | Biochemical and biophysical research communications | 263 | 8579614 |
| 2015 | The NLRP1 inflammasomes. | Immunological reviews | 200 | 25879281 |
| 2018 | Identification of cryptic subunits from an apicomplexan ATP synthase. | eLife | 53 | 30204085 |
| 2019 | Drug Resistance in Protozoan Parasites: An Incessant Wrestle for Survival. | Journal of global antimicrobial resistance | 37 | 30685461 |
| 2019 | The Toxoplasma Vacuolar H+-ATPase Regulates Intracellular pH and Impacts the Maturation of Essential Secretory Proteins. | Cell reports | 35 | 31091451 |
| 2011 | Induction of protective Th1 immune responses in mice by vaccination with recombinant Toxoplasma gondii nucleoside triphosphate hydrolase-II. | Vaccine | 35 | 21315696 |
| 1999 | Recombinant expression, purification, and characterization of Toxoplasma gondii adenosine kinase. | Molecular and biochemical parasitology | 35 | 10514077 |
| 2018 | New life for an old drug: In vitro and in vivo effects of the anthelmintic drug niclosamide against Toxoplasma gondii RH strain. | International journal for parasitology. Drugs and drug resistance | 33 | 30599391 |
| 2016 | P2X7 receptor-dependent tuning of gut epithelial responses to infection. | Immunology and cell biology | 33 | 27559003 |
| 2016 | Inflammatory early events associated to the role of P2X7 receptor in acute murine toxoplasmosis. | Immunobiology | 32 | 28069296 |
| 2010 | Novel roles for ATP-binding cassette G transporters in lipid redistribution in Toxoplasma. | Molecular microbiology | 32 | 20487267 |
| 2022 | The mystery of massive mitochondrial complexes: the apicomplexan respiratory chain. | Trends in parasitology | 30 | 36302692 |
| 2014 | Intestinal immunopathology is associated with decreased CD73-generated adenosine during lethal infection. | Mucosal immunology | 30 | 25389034 |
| 2011 | Identification of Toxoplasma gondii cAMP dependent protein kinase and its role in the tachyzoite growth. | PloS one | 30 | 21799871 |
| 1999 | Characterization of myosin-A and myosin-C: two class XIV unconventional myosins from Toxoplasma gondii. | Cell motility and the cytoskeleton | 29 | 10470019 |
| 2019 | Characterization of the apicoplast-localized enzyme TgUroD in Toxoplasma gondii reveals a key role of the apicoplast in heme biosynthesis. | The Journal of biological chemistry | 28 | 31914409 |
| 2004 | Actin and myosin in Gregarina polymorpha. | Cell motility and the cytoskeleton | 27 | 15083530 |
| 2011 | Structural insight into activation mechanism of Toxoplasma gondii nucleoside triphosphate diphosphohydrolases by disulfide reduction. | The Journal of biological chemistry | 26 | 22130673 |
| 2019 | Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7. | Scientific reports | 25 | 30824738 |
| 2019 | Myrislignan Exhibits Activities Against Toxoplasma gondii RH Strain by Triggering Mitochondrial Dysfunction. | Frontiers in microbiology | 24 | 31620108 |
| 2017 | Diphenyl diselenide modulates nucleotidases, reducing inflammatory responses in the liver of Toxoplasma gondii-infected mice. | Purinergic signalling | 24 | 28815408 |
| 2011 | Extracellular Toxoplasma gondii tachyzoites do not require carbon source uptake for ATP maintenance, gliding motility and invasion in the first hour of their extracellular life. | International journal for parasitology | 24 | 21515276 |
| 2018 | P2X7 receptor-mediated leukocyte recruitment and Porphyromonas gingivalis clearance requires IL-1β production and autocrine IL-1 receptor activation. | Immunobiology | 23 | 30429052 |
| 2024 | Metabolic plasticity, essentiality and therapeutic potential of ribose-5-phosphate synthesis in Toxoplasma gondii. | Nature communications | 11 | 38589375 |
| 2024 | Recognition of phylogenetically diverse pathogens through enzymatically amplified recruitment of RNF213. | EMBO reports | 11 | 39375464 |
| 2024 | The Toxoplasma gondii mitochondrial transporter ABCB7L is essential for the biogenesis of cytosolic and nuclear iron-sulfur cluster proteins and cytosolic translation. | mBio | 9 | 39207139 |
| 2025 | Bumped Kinase Inhibitors Inhibit both Toxoplasma gondii MAPKL1 and CDPK1. | ACS infectious diseases | 7 | 40407244 |
| 2025 | An ISWI-related chromatin remodeller regulates stage-specific gene expression in Toxoplasma gondii. | Nature microbiology | 7 | 40217127 |
| 2025 | Toxoplasma gondii GRA16 Suppresses Aerobic Glycolysis by Downregulating c-Myc and TERT Expressions in Colorectal Cancer Cells. | Biomolecules & therapeutics | 4 | 40556512 |
| 2025 | The critical role of Toxoplasma gondii GRA1 in nutrient salvage. | mBio | 3 | 40576341 |
| 2025 | Activity Evaluation and Mode of Action of ICA Against Toxoplasma gondii In Vitro. | Biomolecules | 3 | 40001505 |
| 2025 | PI3K/Akt/mTOR signaling pathway mediates energy metabolic reprogramming and regulates mitochondrial homeostasis in host cells exposed to Toxoplasma gondii. | Microbiology spectrum | 2 | 41427835 |
| 2025 | Piceatannol Induces Mitochondrial Dysfunction in Toxoplasma gondii. | Microorganisms | 2 | 40572091 |
| 2025 | Proline dehydrogenase, a rate-limiting catabolic enzyme, affecting the growth and pathogenicity of Toxoplasma gondii tachyzoites by regulating the proline metabolism and mitochondrial function of the parasite. | Parasites & vectors | 1 | 40731026 |
| 2025 | Elucidating the Role of Toxoplasma gondii's Mitochondrial Superoxide Dismutase. | Biomolecules | 1 | 40723844 |
| 2026 | Unconventional model organisms bend our view on mitochondrial cristae. | Journal of cell science | 0 | 41789725 |
| 2026 | Inhibition of Toxoplasma gondii proliferation by dimethyl itaconate: Evidence from in vitro and in vivo studies. | PLoS neglected tropical diseases | 0 | 42313860 |
| 2026 | A two-membrane gateway for monocarboxylates couples host glycolysis to Toxoplasma mitochondrial fitness and virulence. | bioRxiv : the preprint server for biology | 0 | 42124602 |
| 2026 | Estudo Abrangente do Resveratrol Associado à Sulfadiazina em Linfócitos Infectados com Toxoplasma gondii: Envolvimento da Sinalização Purinérgica na Resposta Imunológica. | Acta parasitologica | 0 | 41843302 |
| 2025 | Structural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii. | Nature communications | 0 | 41193440 |
| 2025 | Cross-lineage 5-methylcytosine methylome profiling reveals methylated divergence among Toxoplasma gondii tachyzoites of the three major clonal lineages. | Infectious diseases of poverty | 0 | 40830525 |
| 2025 | Impacts of Cipargamin on Na+-ATPase and Osmoregulation of Trypanosoma cruzi. | Membranes | 0 | 41441052 |
| 2025 | TgGloL is an atypical glyoxalase/VOC domain-containing apicoplast protein that is important for the growth of Toxoplasma. | Molecular biology of the cell | 0 | 39878652 |