Affinage · Toxoplasma gondii

DDX17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 · UniProt S8EZK1

Annotated
2026-09-10
32 papers in source corpus 1 papers cited in narrative 1 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

The Toxoplasma gondii DDX17 homolog (TgHoDI) is a DEAD-box RNA helicase that acts as a marker of cytoplasmic mRNA stress granules, which assemble under cellular stress and translational arrest; its helicase function was authenticated by complementation of a yeast Δdhh1 strain (PMID:24709106). Beyond (PMID:24709106), no further mechanistic detail has been characterized in the available corpus.

Mechanistic history

Synthesis pass · year-by-year structured walk · 1 step
  1. 2014 Medium

    Whether the Toxoplasma DEAD-box helicase homolog was a functional helicase and where it acted in the cell was unknown; complementation and imaging established it as a genuine DEAD-box helicase that marks cytoplasmic stress granules forming under translational arrest.

    Evidence Yeast Δdhh1 complementation assay plus live parasite stress granule imaging

    PMID:24709106

    Open questions at the time
    • Direct RNA-unwinding or ATPase activity not measured biochemically
    • In vivo RNA substrates and interacting partners not identified
    • Role in parasite gene regulation or fitness not tested by genetic perturbation

Mechanism profile

Synthesis pass · controlled-vocabulary classification
No controlled-vocabulary terms were assigned to this entry.

Evidence

Reading pass · 1 per-paper finding extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2014 A Toxoplasma gondii DEAD-box RNA helicase homolog, TgHoDI (TG_236650/DDX17 homolog), functions as a marker of cytoplasmic mRNA stress granules that assemble under cellular stress and translational arrest conditions; its function as a DEAD-box helicase was authenticated by complementation of a Δdhh1 yeast strain. Yeast complementation assay (Δdhh1 rescue), live parasite stress granule imaging Gene Medium 24709106

Source papers

Stage 0 corpus · 32 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Acute fatal toxoplasmosis in three Eurasian red squirrels (Sciurus vulgaris) caused by genotype II of Toxoplasma gondii. Journal of wildlife diseases 23 22493121
2012 Potential application of serological tests on fluids from carcasses: detection of antibodies against Toxoplasma gondii and Sarcoptes scabiei in red foxes (Vulpes vulpes). Acta veterinaria Scandinavica 22 22380986
2006 Role of endogenous transplacental transmission in toxoplasmosis in sheep. The Veterinary record 22 17142624
1990 Lesions in fetal pigs with transplacentally-induced toxoplasmosis. Veterinary pathology 22 2278129
2001 Vertical toxoplasmosis in a murine model. Protection after immunization with antigens of Toxoplasma gondii incorporated into liposomes. Memorias do Instituto Oswaldo Cruz 21 11285480
1999 Pregnancy-associated glycoprotein levels in pregnant goats inoculated with Toxoplasma gondii or Listeria monocytogenes: a retrospective study. Theriogenology 21 10735115
1990 Toxoplasmosis and other causes of abortions in sheep from north central United States. Journal of the American Veterinary Medical Association 21 2298653
2018 Seroprevalence and risk factors for selected respiratory and reproductive tract pathogen exposure in European bison (Bison bonasus) in Poland. Veterinary microbiology 20 29426407
1993 Treatment of ovine toxoplasmosis with a combination of sulphamezathine and pyrimethamine. The Veterinary record 20 8488660
1989 Macrophage oxidative metabolism and intracellular Toxoplasma gondii. Microbial pathogenesis 20 2509852
2018 LILRB4 Decrease on uDCs Exacerbate Abnormal Pregnancy Outcomes Following Toxoplasma gondii Infection. Frontiers in microbiology 19 29643846
1977 Toxoplasmosis in sheep. Long-term epidemiological studies in four breeding flocks. Acta veterinaria Scandinavica 19 560112
2021 Pathological Findings in Eurasian Otters (Lutra lutra) Found Dead between 2015-2020 in Schleswig-Holstein, Germany. Animals : an open access journal from MDPI 18 35011165
2021 Intestinal Parasites of Neotropical Wild Jaguars, Pumas, Ocelots, and Jaguarundis in Colombia: Old Friends Brought Back from Oblivion and New Insights. Pathogens (Basel, Switzerland) 17 34209062
2013 Presence of dendritic cells in chicken spleen cell preparations and their functional interaction with the parasite Toxoplasma gondii. Veterinary immunology and immunopathology 17 23477930
2008 Protection against Toxoplasma gondii brain cyst formation in mice immunized with Toxoplasma gondii cytoskeleton proteins and Lactobacillus casei as adjuvant. Veterinary parasitology 17 19111993
1986 Spontaneous toxoplasmosis in canaries (Serinus canaria) and other small passerine cage birds. Avian pathology : journal of the W.V.P.A 17 18766519
1997 Increasing of Toxoplasma gondii (Coccidia, Sarcocystidae) infections by Trypanosoma lewisi (Kinetoplastida, Trypanosomatidae) in white rats. Revista de biologia tropical 16 9458990
2022 Pathology and epidemiology of fatal toxoplasmosis in free-ranging marmosets (Callithrix spp.) from the Brazilian atlantic forest. PLoS neglected tropical diseases 13 36108088
2009 Role of autophagy in the host defense against Toxoplasma gondii in astrocytes. Autophagy 13 19139630
2021 Toxoplasma gondii prevalence in carnivorous wild birds in the eastern United States. International journal for parasitology. Parasites and wildlife 12 34040962
2016 TOXOPLASMA GONDII ANTIBODY PREVALENCE AND TWO NEW GENOTYPES OF THE PARASITE IN ENDANGERED HAWAIIAN GEESE (NENE: BRANTA SANDVICENSIS). Journal of wildlife diseases 12 26967138
2016 First report of systemic toxoplasmosis in a New Zealand sea lion (Phocarctos hookeri). New Zealand veterinary journal 12 27588458
1991 [Effect of table salt on Toxoplasma gondii]. Revista do Instituto de Medicina Tropical de Sao Paulo 12 1844962
1990 Serologic and histologic diagnosis of toxoplasmic abortions in sheep in Oregon. Journal of the American Veterinary Medical Association 12 2105287
1988 Prevention of Toxoplasma gondii abortion in goats by vaccination with oocysts of Hammondia hammondi. Australian veterinary journal 12 3135793
2022 Zoonotic Pathogens in Eurasian Beavers (Castor fiber) in the Netherlands. Journal of wildlife diseases 11 35245369
2014 Characterization of a homolog of DEAD-box RNA helicases in Toxoplasma gondii as a marker of cytoplasmic mRNP stress granules. Gene 11 24709106
2013 Acute fatal toxoplasmosis in a Great Spotted Woodpecker (Dendrocopos major). Journal of wildlife diseases 11 24171576
2024 Pathogen Prevalence in Cetaceans Stranded along the Italian Coastline between 2015 and 2020. Pathogens (Basel, Switzerland) 10 39338953
2023 Broad anti-pathogen potential of DEAD box RNA helicase eIF4A-targeting rocaglates. Scientific reports 10 37291191
2023 Experimental infection of sheep at mid-pregnancy with archetypal type II and type III Toxoplasma gondii isolates exhibited different phenotypic traits. Veterinary parasitology 10 36753878