Affinage · Toxoplasma gondii

COG3

conserved oligomeric Golgi complex subunit 3 · UniProt A0A125YMH1

Annotated
2026-09-10
1 papers in source corpus 1 papers cited in narrative 1 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

COG3 is a subunit of the conserved oligomeric Golgi (COG) complex, which in Toxoplasma gondii tachyzoites is essential for Golgi function and Golgi-mediated protein transport (PMID:37966241). The COG complex in this parasite associates with novel, parasite-specific partners that are themselves critical for protein transport (PMID:37966241). Beyond this identification and functional characterization of the COG complex, no further mechanistic detail specific to COG3 has been characterized in the available corpus.

Mechanistic history

Synthesis pass · year-by-year structured walk · 1 step
  1. 2023 Medium

    Whether an intact COG complex operates in an apicomplexan parasite was unknown; identifying and characterizing the COG complex in T. gondii established that COG3 is part of a functional complex essential for Golgi-mediated protein transport.

    Evidence Identification and functional characterization of the COG complex and its partners in T. gondii tachyzoites

    PMID:37966241

    Open questions at the time
    • The specific contribution of COG3 individually, versus the complex as a whole, is not resolved
    • The identity of the novel COG partners and how they bind COG3 is not specified
    • No structural or biochemical detail of COG3 assembly into the complex is provided

Mechanism profile

Synthesis pass · controlled-vocabulary classification
Partners
NOVEL PARASITE-SPECIFIC COG COMPLEX PARTNERS (IDENTITY NOT SPECIFIED) [#0]
Complex memberships
Conserved oligomeric Golgi (COG) complex

Evidence

Reading pass · 1 per-paper finding extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2023 The conserved oligomeric Golgi (COG) complex, which includes COG3, was identified and characterized in T. gondii tachyzoites, where it plays an essential role in protein transport and Golgi function; novel partners of the COG complex critical for protein transport were also identified. Identification and functional characterization of the COG complex and its partners in T. gondii tachyzoites (study implies loss-of-function and interaction experiments based on identification and characterization language) mBio Medium 37966241

Source papers

Stage 0 corpus · 1 paper · ranked by NIH iCite citations
Year Title Journal Citations PMID
2023 Essential role of the conserved oligomeric Golgi complex in Toxoplasma gondii. mBio 7 37966241