COG1

COG1 is a subunit of the conserved oligomeric Golgi (COG) complex in Toxoplasma gondii tachyzoites, where the complex is essential for Golgi-based protein transport (PMID:37966241). Characterization of the COG complex in this parasite also identified novel, parasite-specific partners that are critical for protein trafficking, indicating the trafficking machinery is elaborated to meet the specific needs of this apicomplexan (PMID:37966241). Beyond this identification and functional characterization (PMID:37966241), no further mechanistic detail about COG1 has been characterized in the available corpus.

1. 2023 Medium

   It was unknown whether an intact COG complex operates in Toxoplasma gondii; identifying and characterizing the complex including COG1 established that it is essential for protein transport in tachyzoites and revealed novel parasite-specific trafficking partners.

   Evidence Genetic and cell-biological characterization of COG complex components and partners in T. gondii tachyzoites

   PMID:37966241

   Open questions at the time

   • The specific molecular function of the COG1 subunit alone, distinct from the assembled complex, is not defined
   • The identity and biochemical role of the novel parasite-specific partners are not detailed at the mechanistic level
   • No structural or interaction map placing COG1 within the complex is provided