COG2

COG2 is a subunit of the conserved oligomeric Golgi (COG) complex in Toxoplasma gondii, which in tachyzoites is essential for protein transport (PMID:37966241). The COG complex associates with novel parasite-specific partners that are critical for its trafficking function (PMID:37966241). Beyond this complex-level characterization, no further COG2-specific mechanistic detail has been characterized in the available corpus.

1. 2023 Medium

   Whether Toxoplasma gondii possesses a functional Golgi trafficking machinery analogous to the COG complex was unresolved; identifying and functionally characterizing the COG complex established it as essential for protein transport in tachyzoites and revealed parasite-specific interacting partners.

   Evidence Functional characterization of the COG complex in T. gondii tachyzoites with identification of novel COG-interacting partners

   PMID:37966241

   Open questions at the time

   • No COG2-specific experiments distinguishing its individual role from the complex as a whole
   • The identities and mechanistic roles of the novel COG-interacting partners are not detailed at the COG2 level
   • No structural or biochemical data on how COG2 assembles into or contributes to the complex