SKA1

SKA1 is a kinetochore component in Apicomplexa, identified as one of 13 previously unknown kinetochore proteins through interactomics and deep homology searches; it belongs to a divergent kinetochore complex that displays nanoscale organization with at least four discrete compartments showing distinct biochemical interactions and subkinetochore localizations (PMID:36006241). Beyond its membership in this complex and its kinetochore localization (PMID:36006241), nothing further about SKA1 is known in the available corpus.

1. 2022 Medium

   Whether Apicomplexa possess a definable kinetochore beyond a few conserved proteins was unknown; interactomics and deep homology searches identified SKA1 among 13 new kinetochore components, establishing it as part of a divergent multi-compartment kinetochore complex.

   Evidence Co-immunoprecipitation/mass spectrometry with deep homology searches and fluorescence localization in Toxoplasma gondii and Plasmodium berghei

   PMID:36006241

   Open questions at the time

   • SKA1 is not individually characterized beyond complex membership and localization
   • The molecular activity and direct binding partners of SKA1 within the complex are not defined
   • Functional consequences of SKA1 loss for spindle attachment or chromosome segregation are not established