COG8

COG8 is a subunit of the conserved oligomeric Golgi (COG) complex in Toxoplasma gondii tachyzoites, a complex that plays an essential role in Golgi-mediated protein transport and is associated with novel partner proteins critical for trafficking in this parasite (PMID:37966241). Beyond this complex-level characterization (PMID:37966241), no further mechanistic detail specific to COG8 has been characterized in the available corpus.

1. 2023 Low

   Whether T. gondii possesses a functional COG complex and how it is organized was unknown; identification of the complex including COG8 established that this parasite maintains a COG-based Golgi trafficking machinery and has expanded it with novel partners.

   Evidence Identification and functional characterization of the COG complex and its partners in T. gondii tachyzoites

   PMID:37966241

   Open questions at the time

   • Abstract-level description with no mechanistic detail specific to COG8's individual role within the complex
   • The specific novel partners and their interactions with COG8 are not resolved
   • No structural or biochemical assignment of COG8 function distinct from the complex