COG4

In Toxoplasma gondii tachyzoites, COG4 is a subunit of the conserved oligomeric Golgi (COG) complex, which is essential for protein transport and Golgi function (PMID:37966241). The COG complex in T. gondii associates with novel parasite-specific partners critical for protein transport (PMID:37966241). Beyond this identification and functional characterization of the COG complex, nothing further is known about COG4 in the available corpus.

1. 2023 Medium

   Whether T. gondii possesses a functional COG complex and what role it plays was unknown; identifying and characterizing the complex established that COG4 is a subunit of a COG complex essential for Golgi function and protein transport in the parasite.

   Evidence Identification and functional characterization of the COG complex and its partners in T. gondii tachyzoites (co-immunoprecipitation, loss-of-function, and subcellular localization assays)

   PMID:37966241

   Open questions at the time

   • The specific molecular activity of COG4 within the complex is not defined
   • The identity of the novel parasite-specific COG partners and how they bind COG4 is not detailed
   • Direct orthogonal validation of COG4's role independent of the complex is not established