Affinage · Toxoplasma gondii

TGME49_321500

RNA recognition motif-containing protein · UniProt S8FBK6

Audit flag: literature coverage
Annotated
2026-09-10
46 papers in source corpus

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

No mechanistic discoveries found in literature.

Mechanism profile

Synthesis pass · controlled-vocabulary classification
No controlled-vocabulary terms were assigned to this entry.

Source papers

Stage 0 corpus · 46 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose. Proceedings of the National Academy of Sciences of the United States of America 318 27382155
2014 Efficient genome engineering of Toxoplasma gondii using CRISPR/Cas9. PloS one 221 24971596
2004 RNA interference in protozoan parasites. Cellular microbiology 205 15104593
2014 Dual transcriptional profiling of mice and Toxoplasma gondii during acute and chronic infection. BMC genomics 162 25240600
2013 Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice. Cell host & microbe 159 23290966
2016 Illuminating uveitis: metagenomic deep sequencing identifies common and rare pathogens. Genome medicine 155 27562436
2005 Biosynthetic labeling of RNA with uracil phosphoribosyltransferase allows cell-specific microarray analysis of mRNA synthesis and decay. Nature biotechnology 153 15685165
2010 NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondii-infected monocytic cells. Infection and immunity 144 21098108
2019 An experimental genetically attenuated live vaccine to prevent transmission of Toxoplasma gondii by cats. Scientific reports 132 30728393
1996 Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells. Infection and immunity 132 8926087
1984 Inhibition of growth of Toxoplasma gondii in cultured fibroblasts by human recombinant gamma interferon. Infection and immunity 131 6425215
2018 P2X7 receptor mediates NLRP3-dependent IL-1β secretion and parasite proliferation in Toxoplasma gondii-infected human small intestinal epithelial cells. Parasites & vectors 125 29291748
2009 Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells. Science (New York, N.Y.) 120 19342550
2016 Detection and visualization of differential splicing in RNA-Seq data with JunctionSeq. Nucleic acids research 108 27257077
2011 RNA interference in protozoan parasites: achievements and challenges. Eukaryotic cell 103 21764910
2016 Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation. Nature immunology 100 27213691
2017 Development of CRISPR/Cas9 for Efficient Genome Editing in Toxoplasma gondii. Methods in molecular biology (Clifton, N.J.) 98 27709570
2015 Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. BMC genomics 98 25757795
1994 Molecular characterization of a 65-kilodalton Toxoplasma gondii antigen expressed abundantly in the matrix of tissue cysts. Molecular and biochemical parasitology 97 7808478
1995 Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii. Implications for the target of macrolide antibiotics. The Journal of clinical investigation 94 7814637
1997 A novel class of unconventional myosins from Toxoplasma gondii. Journal of molecular biology 90 9300060
1993 Cytokine mRNA in the central nervous system of SCID mice infected with Toxoplasma gondii: importance of T-cell-independent regulation of resistance to T. gondii. Infection and immunity 89 8406791
1990 Cloning, expression, and cDNA sequence of surface antigen P22 from Toxoplasma gondii. Molecular and biochemical parasitology 89 2290448
1990 Molecular cloning, sequencing and expression of human interferon-gamma-inducible indoleamine 2,3-dioxygenase cDNA. Biochemical and biophysical research communications 86 2109605
1994 The phylogeny of Neospora caninum and Toxoplasma gondii based on ribosomal RNA sequences. FEMS microbiology letters 85 8039658
2010 A complex small RNA repertoire is generated by a plant/fungal-like machinery and effected by a metazoan-like Argonaute in the single-cell human parasite Toxoplasma gondii. PLoS pathogens 84 20523899
2014 MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway. Neuroscience 82 24657774
2013 Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways. PLoS pathogens 79 24367253
2006 Changes in the expression of human cell division autoantigen-1 influence Toxoplasma gondii growth and development. PLoS pathogens 79 17069459
1999 Phylogenetic analysis based on full-length large subunit ribosomal RNA gene sequence comparison reveals that Neospora caninum is more closely related to Hammondia heydorni than to Toxoplasma gondii. International journal for parasitology 76 10608441
2012 Admixture and recombination among Toxoplasma gondii lineages explain global genome diversity. Proceedings of the National Academy of Sciences of the United States of America 71 22847430
2020 Pathogenic Infection in Male Mice Changes Sperm Small RNA Profiles and Transgenerationally Alters Offspring Behavior. Cell reports 69 32348768
2021 Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis. Cell host & microbe 68 34043960
2004 Mitochondrial tRNA import in Toxoplasma gondii. The Journal of biological chemistry 68 15280394
1997 Adoptive transfer of gut intraepithelial lymphocytes protects against murine infection with Toxoplasma gondii. Journal of immunology (Baltimore, Md. : 1950) 66 9190941
1997 Thiostrepton binds to malarial plastid rRNA. FEBS letters 65 9109400
2013 Toxoplasma gondii infection of fibroblasts causes the production of exosome-like vesicles containing a unique array of mRNA and miRNA transcripts compared to serum starvation. Journal of extracellular vesicles 64 24363837
1997 Comparison of the internal transcribed spacer, ITS 1, from Toxoplasma gondii isolates and Neospora caninum. Parasitology research 63 9089727
2014 Molecular characterisation of Sarcocystis lutrae n. sp. and Toxoplasma gondii from the musculature of two Eurasian otters (Lutra lutra) in Norway. Parasitology research 60 25512210
2018 Human Placental Syncytiotrophoblasts Restrict Toxoplasma gondii Attachment and Replication and Respond to Infection by Producing Immunomodulatory Chemokines. mBio 58 29317509
2014 Differential induction of TLR3-dependent innate immune signaling by closely related parasite species. PloS one 57 24505488
2016 Cerebral complement C1q activation in chronic Toxoplasma infection. Brain, behavior, and immunity 53 27109609
2013 Toxoplasma gondii Alba proteins are involved in translational control of gene expression. Journal of molecular biology 53 23454356
2017 Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against Toxoplasma gondii. Proceedings of the National Academy of Sciences of the United States of America 52 28123064
2011 Protein arginine methylation in parasitic protozoa. Eukaryotic cell 50 21685318
2026 Fragmented rRNAs and lineage-specific RNA-binding proteins define myzozoan mitoribosomes. Trends in parasitology 0 42218085