TGME49_251780
heat shock protein · UniProt A0A125YYP6
- Annotated
- 2026-09-10
84 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 84 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 1998 | Bradyzoite development in Toxoplasma gondii and the hsp70 stress response. | Infection and immunity | 104 | 9632598 |
| 2002 | Heat shock protein 70 is a potential virulence factor in murine toxoplasma infection via immunomodulation of host NF-kappa B and nitric oxide. | Journal of immunology (Baltimore, Md. : 1950) | 91 | 12097402 |
| 2011 | Intracellular protozoan parasites of humans: the role of molecular chaperones in development and pathogenesis. | Protein and peptide letters | 90 | 20955165 |
| 2008 | The transcription of bradyzoite genes in Toxoplasma gondii is controlled by autonomous promoter elements. | Molecular microbiology | 83 | 18433450 |
| 2005 | Toxoplasma gondii Hsp90 is a potential drug target whose expression and subcellular localization are developmentally regulated. | Journal of molecular biology | 83 | 15967463 |
| 2003 | Induction of protective immunity by DNA vaccination with Toxoplasma gondii HSP70, HSP30 and SAG1 genes. | Vaccine | 76 | 12798627 |
| 2000 | Molecular cloning, organellar targeting and developmental expression of mitochondrial chaperone HSP60 in Toxoplasma gondii. | Molecular and biochemical parasitology | 57 | 11163440 |
| 2006 | Toxoplasma gondii-derived heat shock protein 70 stimulates maturation of murine bone marrow-derived dendritic cells via Toll-like receptor 4. | Cell stress & chaperones | 55 | 16572725 |
| 1997 | Heat shock protein 65 induced by gammadelta T cells prevents apoptosis of macrophages and contributes to host defense in mice infected with Toxoplasma gondii. | Journal of immunology (Baltimore, Md. : 1950) | 53 | 9278328 |
| 1999 | Isolation and characterization of a subtractive library enriched for developmentally regulated transcripts expressed during encystation of Toxoplasma gondii. | Molecular and biochemical parasitology | 50 | 10340486 |
| 2005 | Toll-like receptor 4 mediates tolerance in macrophages stimulated with Toxoplasma gondii-derived heat shock protein 70. | Infection and immunity | 46 | 16040976 |
| 1998 | Targeted disruption of the bradyzoite-specific gene BAG1 does not prevent tissue cyst formation in Toxoplasma gondii. | Molecular and biochemical parasitology | 45 | 9657333 |
| 2002 | Toxoplasma gondii-derived heat shock protein HSP70 functions as a B cell mitogen. | Cell stress & chaperones | 43 | 12653480 |
| 2013 | Identification of differentially expressed proteins in sulfadiazine resistant and sensitive strains of Toxoplasma gondii using difference-gel electrophoresis (DIGE). | International journal for parasitology. Drugs and drug resistance | 42 | 24533291 |
| 2005 | Differential subcellular localization of members of the Toxoplasma gondii small heat shock protein family. | Eukaryotic cell | 42 | 16339717 |
| 2003 | Molecular cloning of the 82-kDa heat shock protein (HSP90) of Toxoplasma gondii associated with the entry into and growth in host cells. | Biochemical and biophysical research communications | 40 | 14623321 |
| 2004 | Toxoplasma gondii infection inhibits the development of lupus-like syndrome in autoimmune (New Zealand Black x New Zealand White) F1 mice. | International immunology | 39 | 15148287 |
| 1997 | Bradyzoite-specific gene expression in Toxoplasma gondii requires minimal genomic elements. | Molecular and biochemical parasitology | 38 | 9108551 |
| 1998 | Expression of Toxoplasma gondii-specific heat shock protein 70 during In vivo conversion of bradyzoites to tachyzoites. | Infection and immunity | 37 | 9673286 |
| 2005 | Identification and characterization of cross-reactive antigens from Neospora caninum and Toxoplasma gondii. | Parasitology | 36 | 15991490 |
| 2002 | Roles of IFN-gamma on stage conversion of an obligate intracellular protozoan parasite, Toxoplasma gondii. | International reviews of immunology | 36 | 12486821 |
| 1995 | Mycobacterial 65-kilodalton heat shock protein induces tumor necrosis factor alpha and interleukin 6, reactive nitrogen intermediates, and toxoplasmastatic activity in murine peritoneal macrophages. | Infection and immunity | 34 | 7642277 |
| 1992 | Induction of heat shock protein closely correlates with protection against Toxoplasma gondii infection. | Proceedings of the National Academy of Sciences of the United States of America | 33 | 1557424 |
| 1998 | Gene sequence and transcription differences in 70 kDa heat shock protein correlate with murine virulence of Toxoplasma gondii. | International journal for parasitology | 32 | 9724875 |
| 2002 | Involvement of MyD88 in host defense and the down-regulation of anti-heat shock protein 70 autoantibody formation by MyD88 in Toxoplasma gondii-infected mice. | The Journal of parasitology | 31 | 12435148 |
| 1995 | Heat shock proteins of Toxoplasma gondii. | Parasite immunology | 31 | 8552407 |
| 2017 | Recombinant TgHSP70 Immunization Protects against Toxoplasma gondii Brain Cyst Formation by Enhancing Inducible Nitric Oxide Expression. | Frontiers in cellular and infection microbiology | 29 | 28487847 |
| 2003 | The role of anti-HSP70 autoantibody-forming V(H)1-J(H)1 B-1 cells in Toxoplasma gondii-infected mice. | International immunology | 29 | 12502724 |
| 2011 | Innate immunity in DNA vaccine with Toxoplasma gondii-heat shock protein 70 gene that induces DC activation and Th1 polarization. | Vaccine | 28 | 21236236 |
| 2009 | Isolation of Toxoplasma gondii development mutants identifies a potential proteophosphogylcan that enhances cyst wall formation. | Molecular and biochemical parasitology | 28 | 19879901 |
| 2002 | Roles of NKT cells in resistance against infection with Toxoplasma gondii and in expression of heat shock protein 65 in the host macrophages. | Microbes and infection | 28 | 11825769 |
| 2017 | The heat shock protein 90 of Toxoplasma gondii is essential for invasion of host cells and tachyzoite growth. | Parasite (Paris, France) | 26 | 28627357 |
| 2010 | Direct evidence of O-GlcNAcylation in the apicomplexan Toxoplasma gondii: a biochemical and bioinformatic study. | Amino acids | 25 | 20661758 |
| 2010 | Toxoplasma gondii infection inhibits the mitochondrial apoptosis through induction of Bcl-2 and HSP70. | Parasitology research | 25 | 20680337 |
| 2007 | Molecular phylogenetic analysis in Hammondia-like organisms based on partial Hsp70 coding sequences. | Parasitology | 25 | 17462122 |
| 2015 | The fusion of Toxoplasma gondii SAG1 vaccine candidate to Leishmania infantum heat shock protein 83-kDa improves expression levels in tobacco chloroplasts. | Biotechnology journal | 24 | 25823559 |
| 2023 | Coixol ameliorates Toxoplasma gondii infection-induced lung injury by interfering with T. gondii HSP70/TLR4/NF-κB signaling pathway. | International immunopharmacology | 22 | 36933491 |
| 2013 | N-terminal palmitoylation is required for Toxoplasma gondii HSP20 inner membrane complex localization. | Biochimica et biophysica acta | 22 | 23485398 |
| 2008 | Toxoplasma gondii-derived heat shock protein 70 induces lethal anaphylactic reaction through activation of cytosolic phospholipase A2 and platelet-activating factor via Toll-like receptor 4/myeloid differentiation factor 88. | Microbiology and immunology | 22 | 18667035 |
| 2004 | Identification and characterisation of a regulatory region in the Toxoplasma gondii hsp70 genomic locus. | International journal for parasitology | 22 | 15003494 |
| 2012 | Toxoplasma gondii antigens recognized by IgG antibodies differ between mice with and without active proliferation of tachyzoites in the brain during the chronic stage of infection. | Infection and immunity | 21 | 22851753 |
| 2004 | Toxoplasma gondii-derived heat shock protein 70 stimulates the maturation of human monocyte-derived dendritic cells. | Biochemical and biophysical research communications | 21 | 15336548 |
| 2014 | Natural killer cell intrinsic toll-like receptor MyD88 signaling contributes to IL-12-dependent IFN-γ production by mice during infection with Toxoplasma gondii. | International journal for parasitology | 19 | 24727091 |
| 1993 | Murine peritoneal macrophages activated by the mycobacterial 65-kilodalton heat shock protein express enhanced microbicidal activity in vitro. | Infection and immunity | 18 | 8432607 |
| 2014 | Toxoplasma gondii 70 kDa heat shock protein: systemic detection is associated with the death of the parasites by the immune response and its increased expression in the brain is associated with parasite replication. | PloS one | 16 | 24801069 |
| 2014 | CTL induction by DNA vaccine with Toxoplasma gondii-HSP70 gene. | Parasitology international | 16 | 24448159 |
| 2010 | Evaluation of the antigenic value of recombinant Toxoplasma gondii HSP20 to detect specific immunoglobulin G antibodies in Toxoplasma infected humans. | Experimental parasitology | 16 | 20433835 |
| 2004 | Roles of Toxoplasma gondii-derived heat shock protein 70 in host defense against T. gondii infection. | Microbiology and immunology | 16 | 15557751 |
| 1996 | Contribution of extrathymic gamma delta T cells to the expression of heat-shock protein and to protective immunity in mice infected with Toxoplasma gondii. | Immunology | 15 | 8881756 |
| 1994 | gamma delta T cells play a crucial role in the expression of 65,000 MW heat-shock protein in mice immunized with Toxoplasma antigen. | Immunology | 15 | 7835958 |
| 2011 | Toxoplasma gondii: a bradyzoite-specific DnaK-tetratricopeptide repeat (DnaK-TPR) protein interacts with p23 co-chaperone protein. | Experimental parasitology | 14 | 21281637 |
| 2010 | Protective immunity against lethal anaphylactic reaction in Toxoplasma gondii-infected mice by DNA vaccination with T. gondii-derived heat shock protein 70 gene. | Parasitology international | 14 | 20346412 |
| 2024 | A novel mechanism of resveratrol alleviates Toxoplasma gondii infection-induced pulmonary inflammation via inhibiting inflammasome activation. | Phytomedicine : international journal of phytotherapy and phytopharmacology | 12 | 38851105 |
| 2019 | Plant Hsp90 is a novel adjuvant that elicits a strong humoral and cellular immune response against B- and T-cell epitopes of a Toxoplasma gondii SAG1 peptide. | Parasites & vectors | 12 | 30909938 |
| 1996 | Mechanisms of HSP65 expression induced by gamma delta T cells in murine Toxoplasma gondii infection. | Pathobiology : journal of immunopathology, molecular and cellular biology | 12 | 9031329 |
| 2022 | Resveratrol inhibits Toxoplasma gondii-induced lung injury, inflammatory cascade and evidences of its mechanism of action. | Phytomedicine : international journal of phytotherapy and phytopharmacology | 11 | 36332392 |
| 2021 | Oral Immunization With a Plant HSP90-SAG1 Fusion Protein Produced in Tobacco Elicits Strong Immune Responses and Reduces Cyst Number and Clinical Signs of Toxoplasmosis in Mice. | Frontiers in plant science | 11 | 34675949 |
| 2006 | Anaphylactic reaction induced by Toxoplasma gondii-derived heat shock protein 70. | International immunology | 11 | 16943259 |
| 2000 | The production of a 70 kDa heat shock protein by Toxoplasma gondii RH strain in immunocompromised mice. | International journal for parasitology | 11 | 11428337 |
| 1997 | The role of host-derived heat-shock protein in immunity against Toxoplasma gondii infection. | Parasitology today (Personal ed.) | 11 | 15275133 |
| 2004 | A quantitative assay method of Toxoplasma gondii HSP70 mRNA by quantitative competitive-reverse transcriptase-PCR. | Parasitology international | 10 | 14984835 |
| 2015 | Targeting Heat Shock Proteins 60 and 70 of Toxoplasma gondii as a Potential Drug Target: In Silico Approach. | Interdisciplinary sciences, computational life sciences | 9 | 26297309 |
| 2001 | Role of innate immune cells in protection against Toxoplasma gondii at inflamed site. | The journal of medical investigation : JMI | 9 | 11286020 |
| 2017 | Screening and Identification of the Host Proteins Interacting with Toxoplasma gondii Rhoptry Protein ROP16. | Frontiers in microbiology | 8 | 29255456 |
| 2023 | Protective effect of arctiin against Toxoplasma gondii HSP70-induced allergic acute liver injury by disrupting the TLR4-mediated activation of cytosolic phospholipase A2 and platelet-activating factor. | International immunopharmacology | 7 | 37995571 |
| 2013 | Heat shock protein 40-Gok1 isolation from Toxoplasma gondii RH strain. | Protein and peptide letters | 7 | 24261974 |
| 2018 | Immunization with plasmid DNA expressing Heat Shock Protein 40 confers prophylactic protection against chronic Toxoplasma gondii infection in Kunming mice. | Parasite (Paris, France) | 6 | 30040611 |
| 2018 | Immune Responses Induced by HSP60 DNA Vaccine against Toxoplasma gondii Infection in Kunming Mice. | The Korean journal of parasitology | 6 | 29996627 |
| 2014 | Characterization of the Toxoplasma gondii hsp60 gene sequences from different hosts and geographical locations. | Genetics and molecular research : GMR | 6 | 25177971 |
| 2000 | A role of carboxy-terminal region of Toxoplasma gondii-heat shock protein 70 in enhancement of T. gondii infection in mice. | The Korean journal of parasitology | 6 | 10905074 |
| 1998 | Is there more than one species in the genus Toxoplasma?? | The Tokai journal of experimental and clinical medicine | 6 | 10622636 |
| 1996 | Contribution of 65-kDa heat shock protein induced by gamma and delta T cells to protection against Toxoplasma gondii infection. | Immunologic research | 6 | 8902580 |
| 2024 | Coixol mitigates Toxoplasma gondii infection-induced liver injury by inhibiting the Toxoplasma gondii HSP70/TLR4/NF-κB signaling pathway in hepatic macrophages. | Journal of ethnopharmacology | 5 | 39147001 |
| 2000 | Antigens expressed in feline enteroepithelial-stages parasites of Toxoplasma gondii. | The Journal of veterinary medical science | 5 | 11073080 |
| 2019 | Use of immunological methods to the detection of toxoplasmosis and heat shock protein HSP70 in men. | Journal of parasitic diseases : official organ of the Indian Society for Parasitology | 4 | 31263328 |
| 2013 | Characterization and binding analysis of a microneme adhesive repeat domain-containing protein from Toxoplasma gondii. | Parasitology international | 4 | 24361285 |
| 2010 | Contribution of anti-Hsp70.1 IgG antibody levels to the diagnostic certainty of clinically suspected ocular toxoplasmosis. | Investigative ophthalmology & visual science | 4 | 20554617 |
| 2024 | Toxoplasma gondii bradyzoite-specific BAG1 is nonessential for cyst formation due to compensation by other heat-shock proteins. | Parasites & vectors | 3 | 39080770 |
| 2015 | Sequence Variation in HSP40 Gene among 16 Toxoplasma gondii Isolates from Different Hosts and Geographical Locations. | BioMed research international | 3 | 26613080 |
| 2019 | Heat treatment alleviates the growth and photosynthetic impairment of transplastomic plants expressing Leishmania infantum Hsp83-Toxoplasma gondii SAG1 fusion protein. | Plant science : an international journal of experimental plant biology | 2 | 31084864 |
| 2015 | Toxoplasma Gondii Infection of Chicken Embryos Causes Retinal Changes and Modulates HSP90B1 Gene Expression: A Promising Ocular Toxoplasmosis Model. | European journal of microbiology & immunology | 2 | 26716020 |
| 2025 | Biochemistry of Heat Shock Proteins From Human Intracellular Protozoan Parasites as Diagnostic and Therapeutic Biomarkers. | Biochemistry | 1 | 40452612 |
| 2015 | Isolation and characterization of Heat Shock Protein 100-Batu1 from Toxoplasma gondii RH strain. | Experimental parasitology | 1 | 25728232 |
| 2012 | [Study on construction and immune protective effect of recombinant nucleic acid vaccine of Toxoplasma gondii]. | Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control | 1 | 22799162 |