Affinage · Toxoplasma gondii

TGME49_249720

ATP synthase F0 subunit 9, putative · UniProt A0A125YJV3

Audit flag: literature coverage
Annotated
2026-09-10
46 papers in source corpus

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

No mechanistic discoveries found in literature.

Mechanism profile

Synthesis pass · controlled-vocabulary classification
No controlled-vocabulary terms were assigned to this entry.

Source papers

Stage 0 corpus · 46 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1996 Purification and cloning of a soluble ATP-diphosphohydrolase (apyrase) from potato tubers (Solanum tuberosum). Biochemical and biophysical research communications 263 8579614
2015 The NLRP1 inflammasomes. Immunological reviews 200 25879281
2021 ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria. Nature communications 78 33402698
2009 Particularities of mitochondrial structure in parasitic protists (Apicomplexa and Kinetoplastida). The international journal of biochemistry & cell biology 78 19379828
2015 Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis. PLoS computational biology 75 26001086
1999 Properties and potential-applications of chemical inhibitors of cyclin-dependent kinases. Pharmacology & therapeutics 74 10454205
2009 The role of ATP-binding cassette (ABC) proteins in protozoan parasites. Molecular and biochemical parasitology 73 19464325
1983 A potent nucleoside triphosphate hydrolase from the parasitic protozoan Toxoplasma gondii. Purification, some properties, and activation by thiol compounds. The Journal of biological chemistry 71 6304058
1998 Induced activation of the Toxoplasma gondii nucleoside triphosphate hydrolase leads to depletion of host cell ATP levels and rapid exit of intracellular parasites from infected cells. The Journal of biological chemistry 63 9575188
2000 Vacuolar proton pyrophosphatase activity and pyrophosphate (PPi) in Toxoplasma gondii as possible chemotherapeutic targets. The Biochemical journal 62 10903134
2020 The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches. Annual review of biochemistry 61 32169021
2015 Metabolic Cooperation of Glucose and Glutamine Is Essential for the Lytic Cycle of Obligate Intracellular Parasite Toxoplasma gondii. The Journal of biological chemistry 59 26518878
1996 Comparison of the phosphofructokinase and pyruvate kinase activities of Cryptosporidium parvum, Eimeria tenella and Toxoplasma gondii. Molecular and biochemical parasitology 58 8919992
2016 Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling. The Journal of biological chemistry 54 26933036
2021 Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex. PLoS pathogens 53 33651838
2018 Highly diverged novel subunit composition of apicomplexan F-type ATP synthase identified from Toxoplasma gondii. PLoS biology 38 30005062
2019 Drug Resistance in Protozoan Parasites: An Incessant Wrestle for Survival. Journal of global antimicrobial resistance 37 30685461
2019 The Toxoplasma Vacuolar H+-ATPase Regulates Intracellular pH and Impacts the Maturation of Essential Secretory Proteins. Cell reports 35 31091451
2011 Induction of protective Th1 immune responses in mice by vaccination with recombinant Toxoplasma gondii nucleoside triphosphate hydrolase-II. Vaccine 35 21315696
1999 Recombinant expression, purification, and characterization of Toxoplasma gondii adenosine kinase. Molecular and biochemical parasitology 35 10514077
2018 New life for an old drug: In vitro and in vivo effects of the anthelmintic drug niclosamide against Toxoplasma gondii RH strain. International journal for parasitology. Drugs and drug resistance 33 30599391
2016 P2X7 receptor-dependent tuning of gut epithelial responses to infection. Immunology and cell biology 33 27559003
2016 Inflammatory early events associated to the role of P2X7 receptor in acute murine toxoplasmosis. Immunobiology 32 28069296
2010 Novel roles for ATP-binding cassette G transporters in lipid redistribution in Toxoplasma. Molecular microbiology 32 20487267
2022 The mystery of massive mitochondrial complexes: the apicomplexan respiratory chain. Trends in parasitology 30 36302692
2014 Intestinal immunopathology is associated with decreased CD73-generated adenosine during lethal infection. Mucosal immunology 30 25389034
2011 Identification of Toxoplasma gondii cAMP dependent protein kinase and its role in the tachyzoite growth. PloS one 30 21799871
1999 Characterization of myosin-A and myosin-C: two class XIV unconventional myosins from Toxoplasma gondii. Cell motility and the cytoskeleton 29 10470019
2011 Structural insight into activation mechanism of Toxoplasma gondii nucleoside triphosphate diphosphohydrolases by disulfide reduction. The Journal of biological chemistry 26 22130673
2019 Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7. Scientific reports 25 30824738
2019 Myrislignan Exhibits Activities Against Toxoplasma gondii RH Strain by Triggering Mitochondrial Dysfunction. Frontiers in microbiology 24 31620108
2017 Diphenyl diselenide modulates nucleotidases, reducing inflammatory responses in the liver of Toxoplasma gondii-infected mice. Purinergic signalling 24 28815408
2011 Extracellular Toxoplasma gondii tachyzoites do not require carbon source uptake for ATP maintenance, gliding motility and invasion in the first hour of their extracellular life. International journal for parasitology 24 21515276
2018 P2X7 receptor-mediated leukocyte recruitment and Porphyromonas gingivalis clearance requires IL-1β production and autocrine IL-1 receptor activation. Immunobiology 23 30429052
2024 Metabolic plasticity, essentiality and therapeutic potential of ribose-5-phosphate synthesis in Toxoplasma gondii. Nature communications 11 38589375
2024 Recognition of phylogenetically diverse pathogens through enzymatically amplified recruitment of RNF213. EMBO reports 11 39375464
2024 The Toxoplasma gondii mitochondrial transporter ABCB7L is essential for the biogenesis of cytosolic and nuclear iron-sulfur cluster proteins and cytosolic translation. mBio 9 39207139
2025 Activity Evaluation and Mode of Action of ICA Against Toxoplasma gondii In Vitro. Biomolecules 3 40001505
2025 PI3K/Akt/mTOR signaling pathway mediates energy metabolic reprogramming and regulates mitochondrial homeostasis in host cells exposed to Toxoplasma gondii. Microbiology spectrum 2 41427835
2025 Piceatannol Induces Mitochondrial Dysfunction in Toxoplasma gondii. Microorganisms 2 40572091
2025 Proline dehydrogenase, a rate-limiting catabolic enzyme, affecting the growth and pathogenicity of Toxoplasma gondii tachyzoites by regulating the proline metabolism and mitochondrial function of the parasite. Parasites & vectors 1 40731026
2026 Unconventional model organisms bend our view on mitochondrial cristae. Journal of cell science 0 41789725
2026 Inhibition of Toxoplasma gondii proliferation by dimethyl itaconate: Evidence from in vitro and in vivo studies. PLoS neglected tropical diseases 0 42313860
2026 Estudo Abrangente do Resveratrol Associado à Sulfadiazina em Linfócitos Infectados com Toxoplasma gondii: Envolvimento da Sinalização Purinérgica na Resposta Imunológica. Acta parasitologica 0 41843302
2025 Structural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii. Nature communications 0 41193440
2025 TgGloL is an atypical glyoxalase/VOC domain-containing apicoplast protein that is important for the growth of Toxoplasma. Molecular biology of the cell 0 39878652