Affinage · Toxoplasma gondii

PDX1

pyridoxal 5'-phosphate synthase subunit PDX1 · UniProt S8G4N2

Annotated
2026-09-10
1 papers in source corpus 1 papers cited in narrative 1 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

Toxoplasma gondii PDX1 is a component of the parasite's de novo pyridoxal 5'-phosphate (PLP, vitamin B6) biosynthesis pathway and is required for generating PLP in the parasite (PMID:17222923). Beyond this role in de novo PLP biosynthesis (PMID:17222923), no further mechanistic detail has been characterized in the available corpus.

Mechanistic history

Synthesis pass · year-by-year structured walk · 1 step
  1. 2006 Medium

    Establishing whether T. gondii can synthesize its own vitamin B6 addressed whether the parasite carries a de novo PLP biosynthesis pathway and which subunits drive it; this work identified PDX1 as a required component of that pathway.

    Evidence Biochemical characterization of PLP biosynthesis activity in T. gondii, identifying the de novo pathway components including PDX1

    PMID:17222923

    Open questions at the time
    • The specific catalytic contribution of PDX1 within the synthase complex is not resolved by this study
    • No structural model or interaction partner mapping for the T. gondii enzyme
    • No genetic knockout or in vivo requirement demonstrated

Mechanism profile

Synthesis pass · controlled-vocabulary classification
Complex memberships
pyridoxal 5'-phosphate synthase complex

Evidence

Reading pass · 1 per-paper finding extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 Toxoplasma gondii encodes a functional pyridoxal 5'-phosphate (PLP) de novo biosynthesis pathway; the PDX1 subunit (pyridoxal 5'-phosphate synthase subunit PDX1) is required for PLP biosynthesis in the parasite, as demonstrated by characterization of the enzymatic activity responsible for generating PLP de novo. Biochemical characterization of PLP biosynthesis activity in T. gondii, identifying the de novo pathway components including PDX1 Molecular and biochemical parasitology Medium 17222923

Source papers

Stage 0 corpus · 1 paper · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 The apicomplexan parasite Toxoplasma gondii generates pyridoxal phosphate de novo. Molecular and biochemical parasitology 15 17222923