TGGT1_411760
- Annotated
- 2026-09-10
68 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 68 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2002 | Cytoskeleton of apicomplexan parasites. | Microbiology and molecular biology reviews : MMBR | 352 | 11875126 |
| 2004 | Intracellular parasite invasion strategies. | Science (New York, N.Y.) | 342 | 15073368 |
| 2008 | Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response. | Cell host & microbe | 291 | 18312842 |
| 2003 | Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in apicomplexan parasites. | Molecular cell | 265 | 12718875 |
| 2017 | Gliding motility powers invasion and egress in Apicomplexa. | Nature reviews. Microbiology | 250 | 28867819 |
| 1995 | Invasion of Toxoplasma gondii occurs by active penetration of the host cell. | Journal of cell science | 240 | 7673360 |
| 2006 | Pulling together: an integrated model of Toxoplasma cell invasion. | Current opinion in microbiology | 219 | 16837236 |
| 1997 | Participation of myosin in gliding motility and host cell invasion by Toxoplasma gondii. | Molecular microbiology | 187 | 9383198 |
| 1999 | Time-lapse video microscopy of gliding motility in Toxoplasma gondii reveals a novel, biphasic mechanism of cell locomotion. | Molecular biology of the cell | 158 | 10564254 |
| 2002 | 'The glideosome': a dynamic complex powering gliding motion and host cell invasion by Toxoplasma gondii. | Molecular microbiology | 152 | 12139608 |
| 2007 | Rhoptries: an arsenal of secreted virulence factors. | Current opinion in microbiology | 146 | 17997128 |
| 2003 | Actin filament polymerization regulates gliding motility by apicomplexan parasites. | Molecular biology of the cell | 146 | 12589042 |
| 1996 | Ca(2+)-dependence of conoid extrusion in Toxoplasma gondii tachyzoites. | The Journal of eukaryotic microbiology | 129 | 8720941 |
| 2009 | Host cell entry by apicomplexa parasites requires actin polymerization in the host cell. | Cell host & microbe | 115 | 19286135 |
| 2009 | A novel family of Apicomplexan glideosome-associated proteins with an inner membrane-anchoring role. | The Journal of biological chemistry | 102 | 19561073 |
| 2017 | Toxoplasma gondii F-actin forms an extensive filamentous network required for material exchange and parasite maturation. | eLife | 96 | 28322189 |
| 2000 | Microtubules, but not actin filaments, drive daughter cell budding and cell division in Toxoplasma gondii. | Journal of cell science | 95 | 10704375 |
| 2019 | In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration. | Cell host & microbe | 86 | 31600500 |
| 1999 | Induction of an acrosomal process in Toxoplasma gondii: visualization of actin filaments in a protozoan parasite. | Proceedings of the National Academy of Sciences of the United States of America | 86 | 10430901 |
| 2000 | A dibasic motif in the tail of a class XIV apicomplexan myosin is an essential determinant of plasma membrane localization. | Molecular biology of the cell | 85 | 10749937 |
| 2011 | Evolutionarily divergent, unstable filamentous actin is essential for gliding motility in apicomplexan parasites. | PLoS pathogens | 84 | 21998582 |
| 2004 | Toxoplasma as a novel system for motility. | Current opinion in cell biology | 84 | 15037302 |
| 2008 | Host cell egress and invasion induce marked relocations of glycolytic enzymes in Toxoplasma gondii tachyzoites. | PLoS pathogens | 83 | 18949028 |
| 2015 | Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence. | Nature communications | 80 | 25629393 |
| 2013 | Toxoplasma gondii myosin F, an essential motor for centrosomes positioning and apicoplast inheritance. | The EMBO journal | 77 | 23695356 |
| 2013 | The Toxoplasma protein ARO mediates the apical positioning of rhoptry organelles, a prerequisite for host cell invasion. | Cell host & microbe | 77 | 23498954 |
| 2007 | Evaluation of a real-time PCR assay based on the repetitive B1 gene for the detection of Toxoplasma gondii in human peripheral blood. | Parasitology research | 76 | 17385062 |
| 2001 | Toxoplasma gondii myosins B/C: one gene, two tails, two localizations, and a role in parasite division. | The Journal of cell biology | 73 | 11706051 |
| 2004 | Host cell invasion by the apicomplexans: the significance of microneme protein proteolysis. | Current opinion in microbiology | 72 | 15358257 |
| 2006 | Toll-like receptor recognition of Toxoplasma gondii. | International journal for parasitology | 71 | 16476433 |
| 2015 | Gliding motility in apicomplexan parasites. | Seminars in cell & developmental biology | 70 | 26428297 |
| 2013 | Rapid cytoskeleton remodelling in dendritic cells following invasion by Toxoplasma gondii coincides with the onset of a hypermigratory phenotype. | Cellular microbiology | 69 | 23534541 |
| 2008 | Proteomics and glycomics analyses of N-glycosylated structures involved in Toxoplasma gondii--host cell interactions. | Molecular & cellular proteomics : MCP | 65 | 18187410 |
| 2020 | Evolution, Composition, Assembly, and Function of the Conoid in Apicomplexa. | Trends in parasitology | 63 | 32487504 |
| 2012 | Toxofilin upregulates the host cortical actin cytoskeleton dynamics, facilitating Toxoplasma invasion. | Journal of cell science | 61 | 22641695 |
| 2006 | Regulation of apicomplexan microfilament dynamics by a minimal set of actin-binding proteins. | Traffic (Copenhagen, Denmark) | 61 | 17010119 |
| 2000 | Toxofilin, a novel actin-binding protein from Toxoplasma gondii, sequesters actin monomers and caps actin filaments. | Molecular biology of the cell | 61 | 10637313 |
| 1997 | Cloning and characterization of actin depolymerizing factor from Toxoplasma gondii. | Molecular and biochemical parasitology | 61 | 9274866 |
| 2012 | Impaired chromatin remodelling at STAT1-regulated promoters leads to global unresponsiveness of Toxoplasma gondii-infected macrophages to IFN-γ. | PLoS pathogens | 59 | 22275866 |
| 2004 | Toxoplasma gondii exposes phosphatidylserine inducing a TGF-beta1 autocrine effect orchestrating macrophage evasion. | Biochemical and biophysical research communications | 59 | 15474490 |
| 2009 | Induction and regulation of conoid extrusion in Toxoplasma gondii. | Cellular microbiology | 58 | 19416276 |
| 2013 | The unusual dynamics of parasite actin result from isodesmic polymerization. | Nature communications | 56 | 23921463 |
| 2009 | Toxoplasma gondii actin depolymerizing factor acts primarily to sequester G-actin. | The Journal of biological chemistry | 55 | 20042603 |
| 2009 | A highly sensitive FRET-based approach reveals secretion of the actin-binding protein toxofilin during Toxoplasma gondii infection. | Cellular microbiology | 55 | 19732057 |
| 2011 | Actin depolymerizing factor controls actin turnover and gliding motility in Toxoplasma gondii. | Molecular biology of the cell | 54 | 21346192 |
| 2000 | Cell invasion by un-palatable parasites. | Traffic (Copenhagen, Denmark) | 51 | 11208090 |
| 2019 | Differential requirements for cyclase-associated protein (CAP) in actin-dependent processes of Toxoplasma gondii. | eLife | 50 | 31577230 |
| 2014 | Structure of Toxoplasma gondii coronin, an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 49 | 25114175 |
| 2010 | Structure-based analysis of Toxoplasma gondii profilin: a parasite-specific motif is required for recognition by Toll-like receptor 11. | Journal of molecular biology | 49 | 20851125 |
| 2016 | Dense granule trafficking in Toxoplasma gondii requires a unique class 27 myosin and actin filaments. | Molecular biology of the cell | 45 | 27146112 |
| 2003 | Actin dynamics is controlled by a casein kinase II and phosphatase 2C interplay on Toxoplasma gondii Toxofilin. | Molecular biology of the cell | 45 | 12802063 |
| 2006 | Cellular and molecular mechanics of gliding locomotion in eukaryotes. | International review of cytology | 43 | 16939778 |
| 1999 | Toxoplasma gondii motility and host cell invasiveness are drastically impaired by jasplakinolide, a cyclic peptide stabilizing F-actin. | Microbes and infection | 43 | 10611742 |
| 2024 | Toxoplasma gondii actin filaments are tuned for rapid disassembly and turnover. | Nature communications | 18 | 38418447 |
| 2024 | Cytoskeleton Organization in Formation and Motility of Apicomplexan Parasites. | Annual review of microbiology | 14 | 39094056 |
| 2024 | Emergent actin flows explain distinct modes of gliding motility. | Nature physics | 14 | 39669527 |
| 2024 | Architecture of the Toxoplasma gondii apical polar ring and its role in gliding motility and invasion. | Proceedings of the National Academy of Sciences of the United States of America | 10 | 39514309 |
| 2025 | Atomic models of the Toxoplasma cell invasion machinery. | Nature structural & molecular biology | 7 | 41366525 |
| 2024 | Myosin F controls actin organization and dynamics in Toxoplasma gondii. | Molecular biology of the cell | 6 | 38416592 |
| 2024 | The Toxoplasma secreted effector TgWIP modulates dendritic cell motility by activating host tyrosine phosphatases Shp1 and Shp2. | Cellular and molecular life sciences : CMLS | 4 | 38977495 |
| 2025 | Toxoplasma effector TgWIP hijacks dendritic cell actin and motility via Nck1/Grb2 and the WAVE complex. | mBio | 1 | 41171058 |
| 2025 | Nanobodies in animal infectious disease control: diagnosis and therapy. | Frontiers in cellular and infection microbiology | 1 | 40786610 |
| 2025 | Tepsin and AP4 mediate transport from the trans-Golgi to the plant-like vacuole in toxoplasma. | The Journal of cell biology | 1 | 41082686 |
| 2025 | Cytoskeletal alterations in neuronal cells implicate Toxoplasma gondii secretory machinery and host microRNA-containing extracellular vesicles. | Scientific reports | 1 | 40221584 |
| 2026 | Molecular features of myosin F adapted for driving actin flows in Toxoplasma gondii. | Journal of cell science | 0 | 41995028 |
| 2026 | Tunnelling Nanotube Projections May Interfere with Toxoplasma gondii Interaction with Host Cells. | Microorganisms | 0 | 42197357 |
| 2025 | Toxoplasma effector Tg WIP hijacks dendritic cell actin and motility via Nck1/Grb2 and the WAVE complex. | bioRxiv : the preprint server for biology | 0 | 40667296 |
| 2025 | Molecular features of Myosin F adapted for driving actin flows in Toxoplasma gondii. | bioRxiv : the preprint server for biology | 0 | 41256612 |