{"gene":"TG_309730","gene_symbol":"","run_date":"2026-09-10T21:09:19","timeline":{"discoveries":[],"current_model":""},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null,"strain_conflicts":[]},"prefetch_data":{},"corpus_meta":[{"pmid":"28687608","id":"PMC_28687608","title":"Thioredoxin reductase from Toxoplasma gondii: an essential virulence effector with antioxidant function.","date":"2017","source":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","url":"https://pubmed.ncbi.nlm.nih.gov/28687608","citation_count":36,"is_preprint":false},{"pmid":"33816332","id":"PMC_33816332","title":"Auranofin Resistance in Toxoplasma gondii Decreases the Accumulation of Reactive Oxygen Species but Does Not Target Parasite Thioredoxin Reductase.","date":"2021","source":"Frontiers in cellular and infection microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/33816332","citation_count":12,"is_preprint":false},{"pmid":"40005546","id":"PMC_40005546","title":"Toxoplasma gondii Type I TR and ROP16 Synergistically Downregulate IL-12 to Inhibit Host Reactive Oxygen Species Production.","date":"2025","source":"Pathogens (Basel, Switzerland)","url":"https://pubmed.ncbi.nlm.nih.gov/40005546","citation_count":0,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":4007,"output_tokens":1652,"usd":0.018401,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":6871,"output_tokens":2496,"usd":0.048377,"stage2_stop_reason":"end_turn"},"total_usd":0.074442,"stage1_batch_id":"msgbatch_01S6GjoYQm8LTPUsdhASdqag","stage2_batch_id":"msgbatch_01VX63RTMdBJqsG6gQMqoCjz","note":"batch pricing = 50% of standard","corrective_rerun":"2026-09-10 wrong-gene rerun (round-4 rules)","corrective_reason":"re-read found nothing about this gene"},"stage1_raw":"","stage2_raw":"","audit_flag":null,"strains":[{"strain":"ME49","gene_id":"TGME49_309730","name":null,"product":"thioredoxin reductase","uniprot_acc":"A0A125YKW4","chromosome":"TGME49_chrXI","start_pos":773567},{"strain":"GT1","gene_id":"TGGT1_309730","name":null,"product":"thioredoxin reductase","uniprot_acc":null,"chromosome":"TGGT1_chrXI","start_pos":735920},{"strain":"RH88","gene_id":"TGRH88_049210","name":null,"product":"thioredoxin reductase","uniprot_acc":null,"chromosome":"CM023092","start_pos":821674},{"strain":"VEG","gene_id":"TGVEG_309730","name":null,"product":"thioredoxin reductase","uniprot_acc":"B6KA42","chromosome":"TGVEG_chrXI","start_pos":782571}]}