{"gene":"TG_262860","gene_symbol":"","run_date":"2026-09-10T21:09:19","timeline":{"discoveries":[],"current_model":""},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null,"strain_conflicts":[]},"prefetch_data":{},"corpus_meta":[{"pmid":"19061866","id":"PMC_19061866","title":"ARF6, PI3-kinase and host cell actin cytoskeleton in Toxoplasma gondii cell invasion.","date":"2008","source":"Biochemical and biophysical research communications","url":"https://pubmed.ncbi.nlm.nih.gov/19061866","citation_count":23,"is_preprint":false},{"pmid":"23721065","id":"PMC_23721065","title":"Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells.","date":"2013","source":"BMC microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/23721065","citation_count":18,"is_preprint":false},{"pmid":"35788770","id":"PMC_35788770","title":"A new adenine nucleotide transporter located in the ER is essential for maintaining the growth of Toxoplasma gondii.","date":"2022","source":"PLoS pathogens","url":"https://pubmed.ncbi.nlm.nih.gov/35788770","citation_count":9,"is_preprint":false},{"pmid":"24115522","id":"PMC_24115522","title":"The ATP/ADP substrate specificity switch between Toxoplasma gondii NTPDase1 and NTPDase3 is caused by an altered mode of binding of the substrate base.","date":"2013","source":"Chembiochem : a European journal of chemical biology","url":"https://pubmed.ncbi.nlm.nih.gov/24115522","citation_count":8,"is_preprint":false},{"pmid":"35642006","id":"PMC_35642006","title":"Depletion of Toxoplasma adenine nucleotide translocator leads to defects in mitochondrial morphology.","date":"2022","source":"Parasites & vectors","url":"https://pubmed.ncbi.nlm.nih.gov/35642006","citation_count":8,"is_preprint":false},{"pmid":"18445834","id":"PMC_18445834","title":"Back from the dormant stage: second messenger cyclic ADP-ribose essential for Toxoplasma gondii pathogenicity.","date":"2008","source":"Science signaling","url":"https://pubmed.ncbi.nlm.nih.gov/18445834","citation_count":8,"is_preprint":false},{"pmid":"34858878","id":"PMC_34858878","title":"E-NTPDases: Possible Roles on Host-Parasite Interactions and Therapeutic Opportunities.","date":"2021","source":"Frontiers in cellular and infection microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/34858878","citation_count":7,"is_preprint":false},{"pmid":"32330449","id":"PMC_32330449","title":"Poly(ADP-ribose) metabolism in human parasitic protozoa.","date":"2020","source":"Acta tropica","url":"https://pubmed.ncbi.nlm.nih.gov/32330449","citation_count":6,"is_preprint":false},{"pmid":"37154708","id":"PMC_37154708","title":"Mitochondrial ADP/ATP Carrier 1 Is Important for the Growth of Toxoplasma Tachyzoites.","date":"2023","source":"Microbiology spectrum","url":"https://pubmed.ncbi.nlm.nih.gov/37154708","citation_count":6,"is_preprint":false},{"pmid":"18396434","id":"PMC_18396434","title":"Transient inhibition of poly(ADP-ribose) polymerase expression and activity by Toxoplasma gondii is dispensable for parasite-mediated blockade of host cell apoptosis and intracellular parasite replication.","date":"2007","source":"Microbes and infection","url":"https://pubmed.ncbi.nlm.nih.gov/18396434","citation_count":5,"is_preprint":false},{"pmid":"26112826","id":"PMC_26112826","title":"Kinetic mechanism of Toxoplasma gondii adenosine kinase and the highly efficient utilization of adenosine.","date":"2015","source":"Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology","url":"https://pubmed.ncbi.nlm.nih.gov/26112826","citation_count":5,"is_preprint":false},{"pmid":"32183121","id":"PMC_32183121","title":"Establishment of Novel High-Standard Chemiluminescent Assay for NTPase in Two Protozoans and Its High-Throughput Screening.","date":"2020","source":"Marine drugs","url":"https://pubmed.ncbi.nlm.nih.gov/32183121","citation_count":4,"is_preprint":false},{"pmid":"35938815","id":"PMC_35938815","title":"Nucleoside Triphosphate Hydrolases Assay in Toxoplasm gondii and Neospora caninum for High-Throughput Screening using a Robot Arm.","date":"2022","source":"Journal of visualized experiments : JoVE","url":"https://pubmed.ncbi.nlm.nih.gov/35938815","citation_count":1,"is_preprint":false},{"pmid":"41843302","id":"PMC_41843302","title":"Estudo Abrangente do Resveratrol Associado à Sulfadiazina em Linfócitos Infectados com Toxoplasma gondii: Envolvimento da Sinalização Purinérgica na Resposta Imunológica.","date":"2026","source":"Acta parasitologica","url":"https://pubmed.ncbi.nlm.nih.gov/41843302","citation_count":0,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":11697,"output_tokens":1156,"usd":0.026215,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":6108,"output_tokens":2669,"usd":0.048633,"stage2_stop_reason":"end_turn"},"total_usd":0.074848,"stage1_batch_id":"msgbatch_015xmQKDRqnTh9anE4m7LiD6","stage2_batch_id":"msgbatch_01JLpkFTVhoQBNgqHCKFrVVU","note":"batch pricing = 50% of standard","corrective_rerun":"2026-09-10 wrong-gene rerun (round-4 rules)","corrective_reason":"no remaining paper names this gene"},"stage1_raw":"","stage2_raw":"","audit_flag":{"gene":"TG_262860","tier":"COVERAGE","verdict":"Coverage note","subtype":"corpus_unverifiable","uniprot_band":"empty","rules_fired":"R1","issue":"R1: record has no curated symbol, so its corpus cannot name it (named in 1/39); grounding untestable — coverage note, not a collision"},"strains":[{"strain":"ME49","gene_id":"TGME49_262860","name":null,"product":"ADP-ribosylation factor family protein 1, putative","uniprot_acc":"S8F1Q9","chromosome":"TGME49_chrVIIb","start_pos":971653},{"strain":"GT1","gene_id":"TGGT1_262860","name":null,"product":"putative ADP-ribosylation factor family protein 1","uniprot_acc":null,"chromosome":"TGGT1_chrVIIb","start_pos":946825},{"strain":"RH88","gene_id":"TGRH88_068190","name":null,"product":"putative ADP-ribosylation factor family protein 1","uniprot_acc":null,"chromosome":"CM023089","start_pos":987430},{"strain":"VEG","gene_id":"TGVEG_262860","name":null,"product":"putative ADP-ribosylation factor family protein 1","uniprot_acc":"B9PLN4","chromosome":"TGVEG_chrVIIb","start_pos":981016}]}