{"gene":"TG_218220","gene_symbol":"CRK2","run_date":"2026-09-10T21:09:19","timeline":{"discoveries":[{"year":2002,"finding":"TgCRK2 (a putative cdc2-related kinase) interacts with TgCYC1, a cyclin H-class cyclin identified by yeast two-hybrid screen. TgCYC1 rescued a G1/S cyclin defect in S. cerevisiae, demonstrating it is a functional cyclin partner.","method":"Yeast two-hybrid screen, heterologous complementation in S. cerevisiae","journal":"Molecular and biochemical parasitology","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — yeast two-hybrid interaction plus functional complementation in heterologous system, single lab","pmids":["11897124"],"is_preprint":false,"attribution":[{"species":"Toxoplasma gondii","strain":"RH"}]},{"year":2017,"finding":"TgCrk2 is essential for tachyzoite growth; conditional (tet-OFF) knockdown of TgCrk2 causes G1 phase arrest. TgCrk2 localizes to the cytoplasm and interacts with a P-type cyclin, indicating an atypical mechanism controls G1 progression in T. gondii.","method":"Conditional tet-OFF knockdown, cell cycle analysis, co-immunoprecipitation, immunofluorescence microscopy","journal":"PLoS pathogens","confidence":"High","confidence_rationale":"Tier 2 / Strong — conditional KO with defined G1 arrest phenotype plus co-IP interaction and localization, single lab but multiple orthogonal methods","pmids":["28671988"],"is_preprint":false,"attribution":[{"species":"Toxoplasma gondii","strain":""}]},{"year":2022,"finding":"TgCrk2 forms alternative complexes with three atypical cyclins (TgCycP1, TgCycP2, and TgCyc5) in both RH and ME49 tachyzoites and bradyzoites, constituting the central machinery of the G1 restriction checkpoint (R-point) that governs the switch between parasite growth and bradyzoite differentiation. TgCycP2 regulates G1 duration in developmentally competent ME49 tachyzoites, and TgCyc5 is critical for tissue cyst maturation.","method":"Co-immunoprecipitation, conditional knockdown, cell cycle analysis, global gene expression analysis, differentiation assays (alkaline stress and rat embryonic brain cell models)","journal":"Microbiology spectrum","confidence":"High","confidence_rationale":"Tier 2 / Strong — reciprocal co-IP demonstrating multiple cyclin complexes, conditional KD with defined cell cycle and differentiation phenotypes, multiple orthogonal methods in a single study","pmids":["35652638"],"is_preprint":false,"attribution":[{"species":"Toxoplasma gondii","strain":"RH"},{"species":"Toxoplasma gondii","strain":"ME49"}]},{"year":1998,"finding":"A genomic clone encoding a cdc2-related kinase of T. gondii (CRK2) was isolated and characterised, establishing it as a CDK-related kinase in the parasite.","method":"Genomic cloning and molecular characterisation","journal":"Molecular and biochemical parasitology","confidence":"Low","confidence_rationale":"Tier 3 / Weak — molecular cloning and characterisation only, no functional in vitro assay or phenotypic analysis described in available abstract","pmids":["9719519"],"is_preprint":false,"attribution":[{"species":"Toxoplasma gondii","strain":""}]}],"current_model":"TgCrk2 is a cytoplasmic CDK-related kinase that controls G1 phase progression in Toxoplasma gondii tachyzoites by forming context-dependent complexes with atypical P-type cyclins (TgCycP1, TgCycP2, TgCyc5, and TgCYC1); loss of TgCrk2 causes G1 arrest, and differential cyclin partnerships at the G1 restriction checkpoint regulate the switch between rapid tachyzoite replication and bradyzoite differentiation."},"narrative":{"mechanistic_narrative":"TgCrk2 is a cytoplasmic CDK-related kinase that governs G1 phase progression in Toxoplasma gondii tachyzoites [PMID:28671988]. It is essential for tachyzoite growth: conditional knockdown arrests parasites in G1, establishing TgCrk2 as a control point for cell cycle commitment [PMID:28671988]. Rather than acting through a canonical cyclin, TgCrk2 assembles context-dependent complexes with atypical P-type cyclins — forming alternative complexes with TgCycP1, TgCycP2, and TgCyc5 that constitute the machinery of the G1 restriction checkpoint governing the switch between rapid tachyzoite replication and bradyzoite differentiation [PMID:35652638]. Within this network, TgCycP2 regulates G1 duration in developmentally competent ME49 tachyzoites while TgCyc5 is critical for tissue cyst maturation [PMID:35652638]. TgCrk2 also engages the cyclin H-class cyclin TgCYC1, a functional cyclin partner able to rescue a G1/S cyclin defect in yeast [PMID:11897124]. Beyond these cyclin partnerships and the G1-arrest phenotype, its direct substrates and catalytic mechanism have not been characterized in the available corpus.","teleology":[{"year":1998,"claim":"Establishing whether Toxoplasma encodes a bona fide cell-cycle kinase, the isolation of a cdc2-related kinase gene provided the molecular entry point for studying CDK control in the parasite.","evidence":"genomic cloning and molecular characterisation of T. gondii CRK2","pmids":["9719519"],"confidence":"Low","gaps":["no functional in vitro kinase assay reported","no phenotype or cell-cycle role established","no cyclin partner identified"],"attribution":[{"species":"Toxoplasma gondii","strain":""}]},{"year":2002,"claim":"To determine whether TgCRK2 has a functional cyclin partner, a yeast two-hybrid screen identified the cyclin H-class cyclin TgCYC1, which complemented a yeast G1/S cyclin defect, showing TgCRK2 can engage a functional cyclin.","evidence":"yeast two-hybrid screen with heterologous complementation in S. cerevisiae","pmids":["11897124"],"confidence":"Medium","gaps":["interaction not confirmed in Toxoplasma cells","no demonstration that TgCYC1-TgCRK2 acts at a specific cell-cycle stage in the parasite"],"attribution":[{"species":"Toxoplasma gondii","strain":"RH"}]},{"year":2017,"claim":"To define the cell-cycle role of TgCrk2 in the parasite, conditional knockdown demonstrated it is essential and that its loss arrests parasites in G1, placing TgCrk2 as a cytoplasmic controller of G1 progression through an atypical P-type cyclin partner.","evidence":"conditional tet-OFF knockdown, cell cycle analysis, co-immunoprecipitation, and immunofluorescence in tachyzoites","pmids":["28671988"],"confidence":"High","gaps":["direct kinase substrates not identified","molecular basis of cytoplasmic localization unresolved","identity and number of P-type cyclin partners not fully defined at this stage"],"attribution":[{"species":"Toxoplasma gondii","strain":""}]},{"year":2022,"claim":"To resolve how a single kinase can regulate the growth-versus-differentiation decision, reciprocal co-IP and conditional knockdown showed TgCrk2 forms alternative complexes with TgCycP1, TgCycP2, and TgCyc5 constituting the G1 restriction checkpoint, with distinct cyclins controlling G1 duration versus cyst maturation.","evidence":"reciprocal co-immunoprecipitation, conditional knockdown, cell cycle and differentiation assays (alkaline stress and rat embryonic brain cell models) in RH and ME49","pmids":["35652638"],"confidence":"High","gaps":["biochemical basis of cyclin selectivity not defined","phosphorylation targets that execute the R-point decision unknown","how upstream signals partition TgCrk2 among alternative cyclins unresolved"],"attribution":[{"species":"Toxoplasma gondii","strain":"RH"},{"species":"Toxoplasma gondii","strain":"ME49"}]},{"year":null,"claim":"The direct phosphorylation substrates of TgCrk2 and the structural basis of its selective assembly with atypical P-type versus cyclin H-class cyclins remain unknown.","evidence":"","pmids":[],"confidence":"High","gaps":["no in vitro or in vivo substrate identified","no structural model of TgCrk2-cyclin complexes","mechanism linking cyclin choice to the growth/differentiation switch not defined"],"attribution":[]}],"mechanism_profile":{"molecular_activity":[],"localization":[],"pathway":[],"complexes":["TgCrk2-TgCycP1 complex","TgCrk2-TgCycP2 complex","TgCrk2-TgCyc5 complex","TgCrk2-TgCYC1 complex"],"partners":["TGCYC1 (CYCLIN H-CLASS CYCLIN)","TGCYCP1 (ATYPICAL P-TYPE CYCLIN)","TGCYCP2 (ATYPICAL P-TYPE CYCLIN)","TGCYC5 (ATYPICAL CYCLIN)"],"other_free_text":["Loss of TgCrk2 causes G1 phase arrest and is essential for tachyzoite growth.","Alternative TgCrk2-cyclin complexes constitute the G1 restriction checkpoint (R-point) governing the tachyzoite-to-bradyzoite differentiation switch.","TgCycP2 regulates G1 duration in developmentally competent ME49 tachyzoites; TgCyc5 is critical for tissue cyst maturation."]},"strain_conflicts":[]},"prefetch_data":{},"corpus_meta":[{"pmid":"10873834","id":"PMC_10873834","title":"Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.","date":"2000","source":"Chemistry & biology","url":"https://pubmed.ncbi.nlm.nih.gov/10873834","citation_count":202,"is_preprint":false},{"pmid":"15023358","id":"PMC_15023358","title":"Protein kinases as targets for anti-parasitic chemotherapy.","date":"2004","source":"Biochimica et biophysica acta","url":"https://pubmed.ncbi.nlm.nih.gov/15023358","citation_count":113,"is_preprint":false},{"pmid":"18703066","id":"PMC_18703066","title":"The cell cycle and Toxoplasma gondii cell division: tightly knit or loosely stitched?","date":"2008","source":"International journal for parasitology","url":"https://pubmed.ncbi.nlm.nih.gov/18703066","citation_count":82,"is_preprint":false},{"pmid":"28671988","id":"PMC_28671988","title":"Checkpoints of apicomplexan cell division identified in Toxoplasma gondii.","date":"2017","source":"PLoS pathogens","url":"https://pubmed.ncbi.nlm.nih.gov/28671988","citation_count":59,"is_preprint":false},{"pmid":"15811523","id":"PMC_15811523","title":"Characterization of two T. gondii CK1 isoforms.","date":"2005","source":"Molecular and biochemical parasitology","url":"https://pubmed.ncbi.nlm.nih.gov/15811523","citation_count":26,"is_preprint":false},{"pmid":"11897124","id":"PMC_11897124","title":"Isolation of a Toxoplasma gondii cyclin by yeast two-hybrid interactive screen.","date":"2002","source":"Molecular and biochemical parasitology","url":"https://pubmed.ncbi.nlm.nih.gov/11897124","citation_count":17,"is_preprint":false},{"pmid":"9719519","id":"PMC_9719519","title":"Isolation and characterisation of a genomic clone encoding a cdc2-related kinase of Toxoplasma gondii.","date":"1998","source":"Molecular and biochemical parasitology","url":"https://pubmed.ncbi.nlm.nih.gov/9719519","citation_count":16,"is_preprint":false},{"pmid":"35652638","id":"PMC_35652638","title":"Restriction Checkpoint Controls Bradyzoite Development in Toxoplasma gondii.","date":"2022","source":"Microbiology spectrum","url":"https://pubmed.ncbi.nlm.nih.gov/35652638","citation_count":10,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":10285,"output_tokens":1187,"usd":0.02433,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":6149,"output_tokens":2797,"usd":0.050335,"stage2_stop_reason":"end_turn"},"total_usd":0.074665,"stage1_batch_id":"msgbatch_01WokvBYTB6JLnYrpD4rXnyV","stage2_batch_id":"msgbatch_01M7hsQDvz6AqVC9DLVjQzzc","note":"batch pricing = 50% of standard","corrective_rerun":"2026-09-10 wrong-gene rerun (round-4 rules)","corrective_reason":"paper list: removed papers about other genes"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2002,\n      \"finding\": \"TgCRK2 (a putative cdc2-related kinase) interacts with TgCYC1, a cyclin H-class cyclin identified by yeast two-hybrid screen. TgCYC1 rescued a G1/S cyclin defect in S. cerevisiae, demonstrating it is a functional cyclin partner.\",\n      \"method\": \"Yeast two-hybrid screen, heterologous complementation in S. cerevisiae\",\n      \"journal\": \"Molecular and biochemical parasitology\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — yeast two-hybrid interaction plus functional complementation in heterologous system, single lab\",\n      \"pmids\": [\"11897124\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"RH\"}]\n    },\n    {\n      \"year\": 2017,\n      \"finding\": \"TgCrk2 is essential for tachyzoite growth; conditional (tet-OFF) knockdown of TgCrk2 causes G1 phase arrest. TgCrk2 localizes to the cytoplasm and interacts with a P-type cyclin, indicating an atypical mechanism controls G1 progression in T. gondii.\",\n      \"method\": \"Conditional tet-OFF knockdown, cell cycle analysis, co-immunoprecipitation, immunofluorescence microscopy\",\n      \"journal\": \"PLoS pathogens\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Strong — conditional KO with defined G1 arrest phenotype plus co-IP interaction and localization, single lab but multiple orthogonal methods\",\n      \"pmids\": [\"28671988\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2022,\n      \"finding\": \"TgCrk2 forms alternative complexes with three atypical cyclins (TgCycP1, TgCycP2, and TgCyc5) in both RH and ME49 tachyzoites and bradyzoites, constituting the central machinery of the G1 restriction checkpoint (R-point) that governs the switch between parasite growth and bradyzoite differentiation. TgCycP2 regulates G1 duration in developmentally competent ME49 tachyzoites, and TgCyc5 is critical for tissue cyst maturation.\",\n      \"method\": \"Co-immunoprecipitation, conditional knockdown, cell cycle analysis, global gene expression analysis, differentiation assays (alkaline stress and rat embryonic brain cell models)\",\n      \"journal\": \"Microbiology spectrum\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Strong — reciprocal co-IP demonstrating multiple cyclin complexes, conditional KD with defined cell cycle and differentiation phenotypes, multiple orthogonal methods in a single study\",\n      \"pmids\": [\"35652638\"],\n      \"is_preprint\": false,\n      \"attribution\": [\n        {\"species\": \"Toxoplasma gondii\", \"strain\": \"RH\"},\n        {\"species\": \"Toxoplasma gondii\", \"strain\": \"ME49\"}\n      ]\n    },\n    {\n      \"year\": 1998,\n      \"finding\": \"A genomic clone encoding a cdc2-related kinase of T. gondii (CRK2) was isolated and characterised, establishing it as a CDK-related kinase in the parasite.\",\n      \"method\": \"Genomic cloning and molecular characterisation\",\n      \"journal\": \"Molecular and biochemical parasitology\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 3 / Weak — molecular cloning and characterisation only, no functional in vitro assay or phenotypic analysis described in available abstract\",\n      \"pmids\": [\"9719519\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]\n    }\n  ],\n  \"current_model\": \"TgCrk2 is a cytoplasmic CDK-related kinase that controls G1 phase progression in Toxoplasma gondii tachyzoites by forming context-dependent complexes with atypical P-type cyclins (TgCycP1, TgCycP2, TgCyc5, and TgCYC1); loss of TgCrk2 causes G1 arrest, and differential cyclin partnerships at the G1 restriction checkpoint regulate the switch between rapid tachyzoite replication and bradyzoite differentiation.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"TgCrk2 is a cytoplasmic CDK-related kinase that governs G1 phase progression in Toxoplasma gondii tachyzoites [#1]. It is essential for tachyzoite growth: conditional knockdown arrests parasites in G1, establishing TgCrk2 as a control point for cell cycle commitment [#1]. Rather than acting through a canonical cyclin, TgCrk2 assembles context-dependent complexes with atypical P-type cyclins — forming alternative complexes with TgCycP1, TgCycP2, and TgCyc5 that constitute the machinery of the G1 restriction checkpoint governing the switch between rapid tachyzoite replication and bradyzoite differentiation [#2]. Within this network, TgCycP2 regulates G1 duration in developmentally competent ME49 tachyzoites while TgCyc5 is critical for tissue cyst maturation [#2]. TgCrk2 also engages the cyclin H-class cyclin TgCYC1, a functional cyclin partner able to rescue a G1/S cyclin defect in yeast [#0]. Beyond these cyclin partnerships and the G1-arrest phenotype, its direct substrates and catalytic mechanism have not been characterized in the available corpus.\",\n  \"teleology\": [\n    {\n      \"year\": 1998,\n      \"claim\": \"Establishing whether Toxoplasma encodes a bona fide cell-cycle kinase, the isolation of a cdc2-related kinase gene provided the molecular entry point for studying CDK control in the parasite.\",\n      \"evidence\": \"genomic cloning and molecular characterisation of T. gondii CRK2\",\n      \"pmids\": [\"9719519\"],\n      \"confidence\": \"Low\",\n      \"gaps\": [\"no functional in vitro kinase assay reported\", \"no phenotype or cell-cycle role established\", \"no cyclin partner identified\"],\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2002,\n      \"claim\": \"To determine whether TgCRK2 has a functional cyclin partner, a yeast two-hybrid screen identified the cyclin H-class cyclin TgCYC1, which complemented a yeast G1/S cyclin defect, showing TgCRK2 can engage a functional cyclin.\",\n      \"evidence\": \"yeast two-hybrid screen with heterologous complementation in S. cerevisiae\",\n      \"pmids\": [\"11897124\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"yeast two-hybrid plus heterologous complementation, single lab\",\n      \"gaps\": [\"interaction not confirmed in Toxoplasma cells\", \"no demonstration that TgCYC1-TgCRK2 acts at a specific cell-cycle stage in the parasite\"],\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"RH\"}]\n    },\n    {\n      \"year\": 2017,\n      \"claim\": \"To define the cell-cycle role of TgCrk2 in the parasite, conditional knockdown demonstrated it is essential and that its loss arrests parasites in G1, placing TgCrk2 as a cytoplasmic controller of G1 progression through an atypical P-type cyclin partner.\",\n      \"evidence\": \"conditional tet-OFF knockdown, cell cycle analysis, co-immunoprecipitation, and immunofluorescence in tachyzoites\",\n      \"pmids\": [\"28671988\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"direct kinase substrates not identified\", \"molecular basis of cytoplasmic localization unresolved\", \"identity and number of P-type cyclin partners not fully defined at this stage\"],\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2022,\n      \"claim\": \"To resolve how a single kinase can regulate the growth-versus-differentiation decision, reciprocal co-IP and conditional knockdown showed TgCrk2 forms alternative complexes with TgCycP1, TgCycP2, and TgCyc5 constituting the G1 restriction checkpoint, with distinct cyclins controlling G1 duration versus cyst maturation.\",\n      \"evidence\": \"reciprocal co-immunoprecipitation, conditional knockdown, cell cycle and differentiation assays (alkaline stress and rat embryonic brain cell models) in RH and ME49\",\n      \"pmids\": [\"35652638\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"biochemical basis of cyclin selectivity not defined\", \"phosphorylation targets that execute the R-point decision unknown\", \"how upstream signals partition TgCrk2 among alternative cyclins unresolved\"],\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"RH\"}, {\"species\": \"Toxoplasma gondii\", \"strain\": \"ME49\"}]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"The direct phosphorylation substrates of TgCrk2 and the structural basis of its selective assembly with atypical P-type versus cyclin H-class cyclins remain unknown.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"High\",\n      \"gaps\": [\"no in vitro or in vivo substrate identified\", \"no structural model of TgCrk2-cyclin complexes\", \"mechanism linking cyclin choice to the growth/differentiation switch not defined\"],\n      \"attribution\": []\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\"term_id\": \"GO:0004693\", \"supporting_discovery_ids\": [0, 1, 3], \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"RH\"}, {\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]},\n      {\"term_id\": \"GO:0016301\", \"supporting_discovery_ids\": [3], \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]}\n    ],\n    \"localization\": [\n      {\"term_id\": \"GO:0005737\", \"supporting_discovery_ids\": [1], \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"GO:0000082\", \"supporting_discovery_ids\": [1, 2], \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"RH\"}, {\"species\": \"Toxoplasma gondii\", \"strain\": \"ME49\"}]},\n      {\"term_id\": \"GO:0007049\", \"supporting_discovery_ids\": [1, 2], \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"RH\"}, {\"species\": \"Toxoplasma gondii\", \"strain\": \"ME49\"}]},\n      {\"term_id\": \"GO:0030154\", \"supporting_discovery_ids\": [2], \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"ME49\"}]}\n    ],\n    \"complexes\": [\n      \"TgCrk2-TgCycP1 complex\",\n      \"TgCrk2-TgCycP2 complex\",\n      \"TgCrk2-TgCyc5 complex\",\n      \"TgCrk2-TgCYC1 complex\"\n    ],\n    \"partners\": [\n      \"TgCYC1 (cyclin H-class cyclin)\",\n      \"TgCycP1 (atypical P-type cyclin)\",\n      \"TgCycP2 (atypical P-type cyclin)\",\n      \"TgCyc5 (atypical cyclin)\"\n    ],\n    \"other_free_text\": [\n      \"Loss of TgCrk2 causes G1 phase arrest and is essential for tachyzoite growth.\",\n      \"Alternative TgCrk2-cyclin complexes constitute the G1 restriction checkpoint (R-point) governing the tachyzoite-to-bradyzoite differentiation switch.\",\n      \"TgCycP2 regulates G1 duration in developmentally competent ME49 tachyzoites; TgCyc5 is critical for tissue cyst maturation.\"\n    ]\n  },\n  \"strain_conflicts\": []\n}","audit_flag":null,"strains":[{"strain":"ME49","gene_id":"TGME49_218220","name":"CRK2","product":"CDK-related protein kinase CRK2","uniprot_acc":"A0A125YRL7","chromosome":"TGME49_chrXII","start_pos":1665661},{"strain":"GT1","gene_id":"TGGT1_218220","name":null,"product":"putative cell-cycle-associated protein kinase CDK","uniprot_acc":null,"chromosome":"TGGT1_chrXII","start_pos":1607473},{"strain":"RH88","gene_id":"TGRH88_059130","name":null,"product":"putative cell-cycle-associated protein kinase CDK","uniprot_acc":null,"chromosome":"CM023093","start_pos":1679262},{"strain":"VEG","gene_id":"TGVEG_218220","name":null,"product":"putative cell-cycle-associated protein kinase CDK","uniprot_acc":"A0A0F7V6V4","chromosome":"TGVEG_chrXII","start_pos":1640628}]}