{"gene":"TG_216220","gene_symbol":"AP2XI5","run_date":"2026-09-11T11:01:00","timeline":{"discoveries":[{"year":2013,"finding":"TgAP2XI-5 binds to more than 300 gene promoters and actively controls transcription of genes with peak expression in S and M phases of the tachyzoite cell cycle, including virulence factors packaged in micronemes and rhoptries. The cis-regulatory element recognized by TgAP2XI-5 was identified, and it was demonstrated to actively drive gene transcription.","method":"ChIP, promoter binding assays, identification of cis-regulatory element, transcriptomic analysis","journal":"The Journal of biological chemistry","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — ChIP-based genome-wide promoter binding plus cis-element identification and transcriptional reporter assay in single lab study","pmids":["24025328"],"is_preprint":false,"attribution":[{"species":"Toxoplasma gondii","strain":""}]},{"year":2018,"finding":"TgAP2XI-5 interacts with TgAP2X-5 (identified by co-immunoprecipitation and proteomics). Disruption of TgAP2X-5 leads to defects in TgAP2XI-5 binding at multiple rhoptry gene promoters, demonstrating cooperative binding of these two ApiAP2 transcription factors is required for proper virulence gene expression.","method":"Co-immunoprecipitation, inducible knockdown, RNA-seq, genome-wide ChIP (ChIP-seq)","journal":"Nucleic acids research","confidence":"High","confidence_rationale":"Tier 2 / Strong — reciprocal Co-IP plus genome-wide ChIP-seq showing loss of TgAP2XI-5 binding upon TgAP2X-5 knockdown, multiple orthogonal methods in single study","pmids":["29788176"],"is_preprint":false,"attribution":[{"species":"Toxoplasma gondii","strain":""}]},{"year":2010,"finding":"AP2XI-5 protein expression peaks in a defined temporal window during the tachyzoite cell cycle (S/M-subtranscriptome phase), consistent with its mRNA expression pattern, suggesting cell cycle-regulated protein delivery mediated by AP2 domain promoter recognition specificity.","method":"Transcriptomic profiling of cell cycle stages, protein expression timing analysis","journal":"PloS one","confidence":"Low","confidence_rationale":"Tier 4 / Weak — expression-based inference from transcriptome profiling with no direct functional experiment on AP2XI-5 specifically","pmids":["20865045"],"is_preprint":false,"attribution":[{"species":"Toxoplasma gondii","strain":""}]}],"current_model":"TgAP2XI-5 is a nuclear, cell cycle-regulated transcription factor that binds a defined cis-regulatory DNA element at >300 promoters enriched for S/M-phase virulence genes (microneme and rhoptry genes), activates their transcription, and cooperates with TgAP2X-5 for full binding at rhoptry gene promoters; it is also a component of the essential GCN5b lysine acetyltransferase chromatin-regulatory complex."},"narrative":{"mechanistic_narrative":"TgAP2XI-5 is a cell cycle-regulated ApiAP2 transcription factor in Toxoplasma gondii that binds a defined cis-regulatory DNA element at more than 300 gene promoters and activates transcription of genes with peak expression in the S and M phases of the tachyzoite cell cycle, including virulence factors packaged in micronemes and rhoptries [PMID:24025328]. Full binding at rhoptry gene promoters requires cooperation with a second ApiAP2 factor, TgAP2X-5: the two proteins co-immunoprecipitate, and knockdown of TgAP2X-5 abolishes TgAP2XI-5 promoter occupancy at multiple rhoptry genes [PMID:29788176]. AP2XI-5 protein expression peaks in a defined temporal window during the tachyzoite cell cycle (S/M-subtranscriptome phase), consistent with its mRNA expression pattern, suggesting cell cycle-regulated protein delivery mediated by AP2 domain promoter recognition specificity [PMID:20865045]. Beyond these promoter-binding and partner findings, no structural model or catalytic mechanism has been characterized in the available corpus.","teleology":[{"year":2010,"claim":"Establishing when AP2XI-5 acts required knowing its expression timing; profiling showed protein and mRNA peak in a defined S/M cell cycle window, framing it as a candidate temporal regulator of that subtranscriptome.","evidence":"cell cycle transcriptomic profiling and protein expression timing analysis in tachyzoites","pmids":["20865045"],"confidence":"Low","gaps":["Expression-based inference only, with no direct functional experiment on AP2XI-5","Does not identify target genes or DNA-binding specificity"],"attribution":[{"species":"Toxoplasma gondii","strain":""}]},{"year":2013,"claim":"Whether AP2XI-5 is a bona fide transcriptional regulator with defined targets was open; ChIP plus cis-element identification showed it binds >300 promoters via a specific DNA motif and drives transcription of S/M-phase virulence genes, establishing it as a sequence-specific activator.","evidence":"ChIP, promoter binding assays, cis-element identification, transcriptomic and reporter analysis in T. gondii","pmids":["24025328"],"confidence":"Medium","gaps":["Single-lab study without genome-wide ChIP-seq resolution","Direct activation shown by reporter but native regulatory mechanism not dissected"],"attribution":[{"species":"Toxoplasma gondii","strain":""}]},{"year":2018,"claim":"Whether AP2XI-5 acts alone at virulence promoters was unknown; reciprocal Co-IP and ChIP-seq showed it partners with TgAP2X-5, and TgAP2X-5 knockdown abolishes AP2XI-5 binding at multiple rhoptry gene promoters, establishing cooperative combinatorial control of virulence gene expression.","evidence":"reciprocal Co-IP, inducible knockdown, RNA-seq and genome-wide ChIP-seq in T. gondii","pmids":["29788176"],"confidence":"High","gaps":["Mechanism of cooperativity (adjacent motifs vs. protein-protein tethering) not resolved","Does not address microneme promoters equivalently to rhoptry promoters"],"attribution":[{"species":"Toxoplasma gondii","strain":""}]}],"mechanism_profile":{"molecular_activity":[],"localization":[],"pathway":[],"complexes":[],"partners":["TGAP2X-5 (COOPERATIVE APIAP2 PARTNER AT RHOPTRY PROMOTERS)"],"other_free_text":["Binds a defined cis-regulatory DNA element at >300 promoters enriched for S/M-phase virulence genes (microneme and rhoptry genes)","Protein expression peaks in the S/M window of the tachyzoite cell cycle"]},"strain_conflicts":[]},"prefetch_data":{},"corpus_meta":[{"pmid":"20865045","id":"PMC_20865045","title":"Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondii.","date":"2010","source":"PloS one","url":"https://pubmed.ncbi.nlm.nih.gov/20865045","citation_count":234,"is_preprint":false},{"pmid":"29932347","id":"PMC_29932347","title":"The Epigenome, Cell Cycle, and Development in Toxoplasma.","date":"2018","source":"Annual review of microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/29932347","citation_count":51,"is_preprint":false},{"pmid":"20657661","id":"PMC_20657661","title":"The construction and use of log-odds substitution scores for multiple sequence alignment.","date":"2010","source":"PLoS computational biology","url":"https://pubmed.ncbi.nlm.nih.gov/20657661","citation_count":48,"is_preprint":false},{"pmid":"24025328","id":"PMC_24025328","title":"Toxoplasma transcription factor TgAP2XI-5 regulates the expression of genes involved in parasite virulence and host invasion.","date":"2013","source":"The Journal of biological chemistry","url":"https://pubmed.ncbi.nlm.nih.gov/24025328","citation_count":39,"is_preprint":false},{"pmid":"29788176","id":"PMC_29788176","title":"Cooperative binding of ApiAP2 transcription factors is crucial for the expression of virulence genes in Toxoplasma gondii.","date":"2018","source":"Nucleic acids research","url":"https://pubmed.ncbi.nlm.nih.gov/29788176","citation_count":35,"is_preprint":false},{"pmid":"22486860","id":"PMC_22486860","title":"Cactin is essential for G1 progression in Toxoplasma gondii.","date":"2012","source":"Molecular microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/22486860","citation_count":23,"is_preprint":false},{"pmid":"25393307","id":"PMC_25393307","title":"Distinct strains of Toxoplasma gondii feature divergent transcriptomes regardless of developmental stage.","date":"2014","source":"PloS one","url":"https://pubmed.ncbi.nlm.nih.gov/25393307","citation_count":22,"is_preprint":false},{"pmid":"18983845","id":"PMC_18983845","title":"New eukaryotic systematics: a phylogenetic perspective of developmental gene expression in the Apicomplexa.","date":"2008","source":"International journal for parasitology","url":"https://pubmed.ncbi.nlm.nih.gov/18983845","citation_count":12,"is_preprint":false},{"pmid":"39690155","id":"PMC_39690155","title":"Apicomplexan mitoribosome from highly fragmented rRNAs to a functional machine.","date":"2024","source":"Nature communications","url":"https://pubmed.ncbi.nlm.nih.gov/39690155","citation_count":9,"is_preprint":false},{"pmid":"36178892","id":"PMC_36178892","title":"Genomic insights into host and parasite interactions during intracellular infection by Toxoplasma gondii.","date":"2022","source":"PloS one","url":"https://pubmed.ncbi.nlm.nih.gov/36178892","citation_count":2,"is_preprint":false},{"pmid":"42087241","id":"PMC_42087241","title":"Host-cell dependent epigenetic profiles associated with survival outcomes in T. gondii infection.","date":"2026","source":"Epigenetics & chromatin","url":"https://pubmed.ncbi.nlm.nih.gov/42087241","citation_count":0,"is_preprint":false},{"pmid":"41278634","id":"PMC_41278634","title":"Single-cell analysis of brain-derived Toxoplasma bradyzoites reveals a novel cell cycle regulated by AP2XI-6.","date":"2025","source":"bioRxiv : the preprint server for biology","url":"https://pubmed.ncbi.nlm.nih.gov/41278634","citation_count":0,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":21864,"output_tokens":1623,"usd":0.044969,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":6777,"output_tokens":2695,"usd":0.05063,"stage2_stop_reason":"end_turn"},"total_usd":0.099332,"stage1_batch_id":"msgbatch_01WokvBYTB6JLnYrpD4rXnyV","stage2_batch_id":"msgbatch_01M7hsQDvz6AqVC9DLVjQzzc","note":"batch pricing = 50% of standard","corrective_rerun":"2026-09-10 wrong-gene rerun (round-4 rules)","corrective_reason":"summary amended","hand_review_patch":"2026-09-11 AK hand-review verdicts (handoff/tools_2026-09-11/patch)","hand_review_verdict":"edit"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2013,\n      \"finding\": \"TgAP2XI-5 binds to more than 300 gene promoters and actively controls transcription of genes with peak expression in S and M phases of the tachyzoite cell cycle, including virulence factors packaged in micronemes and rhoptries. The cis-regulatory element recognized by TgAP2XI-5 was identified, and it was demonstrated to actively drive gene transcription.\",\n      \"method\": \"ChIP, promoter binding assays, identification of cis-regulatory element, transcriptomic analysis\",\n      \"journal\": \"The Journal of biological chemistry\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — ChIP-based genome-wide promoter binding plus cis-element identification and transcriptional reporter assay in single lab study\",\n      \"pmids\": [\"24025328\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2018,\n      \"finding\": \"TgAP2XI-5 interacts with TgAP2X-5 (identified by co-immunoprecipitation and proteomics). Disruption of TgAP2X-5 leads to defects in TgAP2XI-5 binding at multiple rhoptry gene promoters, demonstrating cooperative binding of these two ApiAP2 transcription factors is required for proper virulence gene expression.\",\n      \"method\": \"Co-immunoprecipitation, inducible knockdown, RNA-seq, genome-wide ChIP (ChIP-seq)\",\n      \"journal\": \"Nucleic acids research\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Strong — reciprocal Co-IP plus genome-wide ChIP-seq showing loss of TgAP2XI-5 binding upon TgAP2X-5 knockdown, multiple orthogonal methods in single study\",\n      \"pmids\": [\"29788176\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2010,\n      \"finding\": \"AP2XI-5 protein expression peaks in a defined temporal window during the tachyzoite cell cycle (S/M-subtranscriptome phase), consistent with its mRNA expression pattern, suggesting cell cycle-regulated protein delivery mediated by AP2 domain promoter recognition specificity.\",\n      \"method\": \"Transcriptomic profiling of cell cycle stages, protein expression timing analysis\",\n      \"journal\": \"PloS one\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 4 / Weak — expression-based inference from transcriptome profiling with no direct functional experiment on AP2XI-5 specifically\",\n      \"pmids\": [\"20865045\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2014,\n      \"finding\": \"GCN5b co-immunoprecipitates with AP2-domain proteins including AP2XI-5, indicating TgAP2XI-5 is a component of the GCN5b lysine acetyltransferase transcriptional complex in Toxoplasma.\",\n      \"method\": \"Proteomics/co-immunoprecipitation of GCN5b followed by mass spectrometry\",\n      \"journal\": \"PLoS pathogens\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 3 / Moderate — single Co-IP/MS identifying AP2XI-5 as GCN5b interactor, replicated in concept by a subsequent study (PMID:31381949)\",\n      \"pmids\": [\"24391497\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2019,\n      \"finding\": \"GCN5b co-immunoprecipitates with AP2XI-5 under normal tachyzoite culture conditions, confirming TgAP2XI-5 as a component of a GCN5b-associated transcriptional complex. Reciprocal co-IPs with distinct AP2 factors help delineate at least two distinct GCN5b-containing complexes.\",\n      \"method\": \"Co-immunoprecipitation (reciprocal) under normal and bradyzoite-inducing conditions, mass spectrometry\",\n      \"journal\": \"Molecular and biochemical parasitology\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 3 / Moderate — reciprocal Co-IP with MS, single lab, corroborates earlier finding (PMID:24391497)\",\n      \"pmids\": [\"31381949\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2012,\n      \"finding\": \"PPMO directed against AP2XI-3 (a related ApiAP2, not AP2XI-5) restricted intracellular parasite replication, validating AP2XI-3 as a molecular target. NOTE: this finding is for AP2XI-3, not AP2XI-5.\",\n      \"method\": \"Antisense PPMO knockdown, replication assay in vitro\",\n      \"journal\": \"Proceedings of the National Academy of Sciences of the United States of America\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 3 / Weak — this is AP2XI-3, not AP2XI-5; included only as contextual neighbor, single method\",\n      \"pmids\": [\"22891343\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]\n    }\n  ],\n  \"current_model\": \"TgAP2XI-5 is a nuclear, cell cycle-regulated transcription factor that binds a defined cis-regulatory DNA element at >300 promoters enriched for S/M-phase virulence genes (microneme and rhoptry genes), activates their transcription, and cooperates with TgAP2X-5 for full binding at rhoptry gene promoters; it is also a component of the essential GCN5b lysine acetyltransferase chromatin-regulatory complex.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"TgAP2XI-5 is a cell cycle-regulated ApiAP2 transcription factor in Toxoplasma gondii that binds a defined cis-regulatory DNA element at more than 300 gene promoters and activates transcription of genes with peak expression in the S and M phases of the tachyzoite cell cycle, including virulence factors packaged in micronemes and rhoptries [#0]. Full binding at rhoptry gene promoters requires cooperation with a second ApiAP2 factor, TgAP2X-5: the two proteins co-immunoprecipitate, and knockdown of TgAP2X-5 abolishes TgAP2XI-5 promoter occupancy at multiple rhoptry genes [#1]. TgAP2XI-5 additionally associates with the GCN5b lysine acetyltransferase complex, linking its promoter recognition to chromatin-modifying activity [#3, #4]. Beyond these promoter-binding, partner, and complex-membership findings, no structural model or catalytic mechanism has been characterized in the available corpus.\",\n  \"teleology\": [\n    {\n      \"year\": 2010,\n      \"claim\": \"Establishing when AP2XI-5 acts required knowing its expression timing; profiling showed protein and mRNA peak in a defined S/M cell cycle window, framing it as a candidate temporal regulator of that subtranscriptome.\",\n      \"evidence\": \"cell cycle transcriptomic profiling and protein expression timing analysis in tachyzoites\",\n      \"pmids\": [\"20865045\"],\n      \"confidence\": \"Low\",\n      \"gaps\": [\"Expression-based inference only, with no direct functional experiment on AP2XI-5\", \"Does not identify target genes or DNA-binding specificity\"],\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2013,\n      \"claim\": \"Whether AP2XI-5 is a bona fide transcriptional regulator with defined targets was open; ChIP plus cis-element identification showed it binds >300 promoters via a specific DNA motif and drives transcription of S/M-phase virulence genes, establishing it as a sequence-specific activator.\",\n      \"evidence\": \"ChIP, promoter binding assays, cis-element identification, transcriptomic and reporter analysis in T. gondii\",\n      \"pmids\": [\"24025328\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Single-lab study without genome-wide ChIP-seq resolution\", \"Direct activation shown by reporter but native regulatory mechanism not dissected\"],\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2014,\n      \"claim\": \"How AP2XI-5 might couple DNA binding to chromatin state was unaddressed; GCN5b Co-IP/MS identified AP2XI-5 as a component of the GCN5b lysine acetyltransferase complex, linking it to histone acetylation machinery.\",\n      \"evidence\": \"GCN5b Co-IP followed by mass spectrometry in tachyzoites\",\n      \"pmids\": [\"24391497\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Single Co-IP/MS without reciprocal validation at this stage\", \"Does not establish whether AP2XI-5 recruits GCN5b to its target promoters\"],\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2018,\n      \"claim\": \"Whether AP2XI-5 acts alone at virulence promoters was unknown; reciprocal Co-IP and ChIP-seq showed it partners with TgAP2X-5, and TgAP2X-5 knockdown abolishes AP2XI-5 binding at multiple rhoptry gene promoters, establishing cooperative combinatorial control of virulence gene expression.\",\n      \"evidence\": \"reciprocal Co-IP, inducible knockdown, RNA-seq and genome-wide ChIP-seq in T. gondii\",\n      \"pmids\": [\"29788176\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"Mechanism of cooperativity (adjacent motifs vs. protein-protein tethering) not resolved\", \"Does not address microneme promoters equivalently to rhoptry promoters\"],\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2019,\n      \"claim\": \"Whether the GCN5b association was robust and singular was open; reciprocal Co-IP/MS confirmed AP2XI-5 in a GCN5b-associated complex and delineated at least two distinct GCN5b-containing complexes marked by different AP2 factors.\",\n      \"evidence\": \"reciprocal Co-IP/MS under normal and bradyzoite-inducing conditions in tachyzoites\",\n      \"pmids\": [\"31381949\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Complex composition and stoichiometry not fully defined\", \"Functional consequence of AP2XI-5 residence in GCN5b complex not tested by loss-of-function\"],\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"The catalytic/structural basis of AP2XI-5 DNA recognition and whether its loss functionally impairs virulence gene expression and parasite fitness remain unestablished.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Low\",\n      \"gaps\": [\"No AP2XI-5 loss-of-function phenotype reported in the corpus\", \"No structural model of the AP2 domain-DNA interface\", \"Whether AP2XI-5 recruits GCN5b acetyltransferase activity to its target promoters is untested\"],\n      \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\"term_id\": \"GO:0003700\", \"supporting_discovery_ids\": [0], \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]},\n      {\"term_id\": \"GO:0000976\", \"supporting_discovery_ids\": [0, 1], \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]},\n      {\"term_id\": \"GO:0045893\", \"supporting_discovery_ids\": [0], \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]}\n    ],\n    \"localization\": [\n      {\"term_id\": \"GO:0005634\", \"supporting_discovery_ids\": [0], \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"GO:0006357\", \"supporting_discovery_ids\": [0, 1], \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]},\n      {\"term_id\": \"GO:0007049\", \"supporting_discovery_ids\": [2], \"attribution\": [{\"species\": \"Toxoplasma gondii\", \"strain\": \"\"}]}\n    ],\n    \"complexes\": [\n      \"GCN5b lysine acetyltransferase transcriptional complex\"\n    ],\n    \"partners\": [\n      \"TgAP2X-5 (cooperative ApiAP2 partner at rhoptry promoters)\",\n      \"GCN5b (lysine acetyltransferase)\"\n    ],\n    \"other_free_text\": [\n      \"Binds a defined cis-regulatory DNA element at >300 promoters enriched for S/M-phase virulence genes (microneme and rhoptry genes)\",\n      \"Protein expression peaks in the S/M window of the tachyzoite cell cycle\"\n    ]\n  },\n  \"strain_conflicts\": []\n}","audit_flag":null,"strains":[{"strain":"ME49","gene_id":"TGME49_216220","name":"AP2XI5","product":"AP2 domain transcription factor AP2XI-5","uniprot_acc":"A0A125YFX0","chromosome":"TGME49_chrXI","start_pos":6309348},{"strain":"GT1","gene_id":"TGGT1_216220","name":null,"product":"AP2 domain transcription factor AP2XI-5","uniprot_acc":null,"chromosome":"TGGT1_chrXI","start_pos":6230908},{"strain":"RH88","gene_id":"TGRH88_056350","name":null,"product":"AP2 domain transcription factor AP2XI-5","uniprot_acc":null,"chromosome":"CM023092","start_pos":6369953},{"strain":"VEG","gene_id":"TGVEG_216220","name":null,"product":"AP2 domain transcription factor AP2XI-5","uniprot_acc":"A0A125YFX1","chromosome":"TGVEG_chrXI","start_pos":6305321}]}